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A prospective, non comparative, multicenter study to investigate the effect of cadexomer iodine on bioburden load and other wound characteristics in diabetic foot ulcers.
MedLine Citation:
PMID:  23136838     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Few studies regarding wound treatment with topical antimicrobials evaluate change in the bacterial bioburden of the wound with treatment. This study sought out to determine the in vivo effect of cadexomer iodine antibacterial dressing on diabetic foot ulcers (DFUs) that were infected or achieved a critical level of colonisation, looking specifically at wound progression in relation to bioburden. Fifteen patients corresponding to 16 total DFUs met criteria of displaying clinical signs of infection or critical colonisation and were suitable for a topical antibacterial dressing. They underwent weekly treatment for 6 weeks. Cultures were taken at week 0, 3 and 6 as appropriate. At week 6 median log(10) bacterial count reduction of 1.0 was observed from baseline (p = 0·025). At week 3- a median log(10) bacterial count reduction of 0.3 was observed from baseline (p = 0·049). Over the study period there was a 53.6% median reduction of the wound surface area. There were no patients that completely healed their ulcer over the 6 week study period. There was a statistically significant median reduction in the bacterial load over the 6 week period (p = 0·025) as well as 3 weeks (p = 0·049). This was accompanied by a median reduction of 53.6% in ulcer surface area and 50% in ulcer depth from baseline to final.
Authors:
Jamie A Schwartz; John C Lantis; Cynthia Gendics; Amy M Fuller; Wyatt Payne; Diane Ochs
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  International wound journal     Volume:  -     ISSN:  1742-481X     ISO Abbreviation:  Int Wound J     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230907     Medline TA:  Int Wound J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. International Wound Journal © 2012 Blackwell Publishing Ltd and Medicalhelplines.com Inc.
Affiliation:
JA Schwartz, MD, Division of Vascular Clinical Research, Department of Surgery, St. Luke's-Roosevelt Hospital Center, Columbia University, New York, NY, USA JC Lantis II, MD, Division of Vascular Clinical Research, Department of Surgery, St. Luke's-Roosevelt Hospital Center, Columbia University, New York, NY, USA C Gendics, RN, Division of Vascular Clinical Research, Department of Surgery, St. Luke's-Roosevelt Hospital Center, Columbia University, New York, NY, USA AM Fuller, BS, Division of Vascular Clinical Research, Department of Surgery, St. Luke's-Roosevelt Hospital Center, Columbia University, New York, NY, USA W Payne, MD, Institute for Tissue Regeneration, Repair, and Rehabilitation, Bay Pines VA Healthcare System, Bay Pines, FL, USA D Ochs, RN, Institute for Tissue Regeneration, Repair, and Rehabilitation, Bay Pines VA Healthcare System, Bay Pines, FL, USA.
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