Document Detail

A prospective multicentre survey on the treatment of acute pancreatitis in Italy.
MedLine Citation:
PMID:  17602904     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The Italian Association for the Study of the Pancreas released a diagnostic and therapeutic algorithm for acute pancreatitis in 1999. AIM: This study focused on the analysis of the therapeutic approach for the treatment of acute pancreatitis in Italy. PATIENTS: One thousand, one hundred and seventy-three patients were recruited: 1006 patients (85.8%) had mild acute pancreatitis (MAP) and 167 (14.2%) had the severe acute pancreatitis (SAP); 161 patients showed pancreatic necrosis at computed tomography; 121 patients (10.3%) had sequelae and 36 (3.1%) died. RESULTS: Non-steroidal anti-inflammatory drugs and tramadol were used more frequently in patients with the MAP whereas opioids and the association schedules were used more frequently in patients with the SAP (P<0.001). Gabexate mesilate was utilised in 831 out of 1173 patients (70.8%); in particular, gabexate mesilate was used in 70.6% patients with MAP and in 73.1% of those with SAP (P=0.521). The duration of the drug administration was significantly shorter in those having MAP than in those having the SAP (P<0.001). The antibiotics most frequently used for the prophylaxis against infection from pancreatic necrosis (43.1%) were carbapenems. Only a small number of patients received enteral nutrition (4.7%). Endoscopic retrograde cholangiopancreatography was carried out in 344 of the 1173 patients (29.3%). Surgery was performed in 48 with SAP (19 had elective biliary surgery and 29 had pancreatic surgery). CONCLUSIONS: The results of this survey indicate a lack of compliance with the guidelines which regard the indications mainly for interventional endoscopy and surgery.
R Pezzilli; G Uomo; A Gabbrielli; A Zerbi; L Frulloni; P De Rai; L Castoldi; G Cavallini; V Di Carlo;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2007-06-29
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  39     ISSN:  1590-8658     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  838-46     Citation Subset:  IM    
Department of Internal Medicine and Gastroenterology, S. Orsola-Malpighi Hospital, Bologna, Italy.
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MeSH Terms
Aged, 80 and over
Analgesics / therapeutic use
Anti-Bacterial Agents / therapeutic use
Digestive System Surgical Procedures / statistics & numerical data
Histamine Antagonists / therapeutic use
Italy / epidemiology
Middle Aged
Pancreatitis / drug therapy*,  epidemiology,  surgery*
Prospective Studies
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Analgesics; 0/Anti-Bacterial Agents; 0/Histamine Antagonists
Comment In:
Dig Liver Dis. 2007 Sep;39(9):847-8   [PMID:  17652040 ]

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