| A prospective multicentre survey on the treatment of acute pancreatitis in Italy. | |
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MedLine Citation:
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PMID: 17602904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The Italian Association for the Study of the Pancreas released a diagnostic and therapeutic algorithm for acute pancreatitis in 1999. AIM: This study focused on the analysis of the therapeutic approach for the treatment of acute pancreatitis in Italy. PATIENTS: One thousand, one hundred and seventy-three patients were recruited: 1006 patients (85.8%) had mild acute pancreatitis (MAP) and 167 (14.2%) had the severe acute pancreatitis (SAP); 161 patients showed pancreatic necrosis at computed tomography; 121 patients (10.3%) had sequelae and 36 (3.1%) died. RESULTS: Non-steroidal anti-inflammatory drugs and tramadol were used more frequently in patients with the MAP whereas opioids and the association schedules were used more frequently in patients with the SAP (P<0.001). Gabexate mesilate was utilised in 831 out of 1173 patients (70.8%); in particular, gabexate mesilate was used in 70.6% patients with MAP and in 73.1% of those with SAP (P=0.521). The duration of the drug administration was significantly shorter in those having MAP than in those having the SAP (P<0.001). The antibiotics most frequently used for the prophylaxis against infection from pancreatic necrosis (43.1%) were carbapenems. Only a small number of patients received enteral nutrition (4.7%). Endoscopic retrograde cholangiopancreatography was carried out in 344 of the 1173 patients (29.3%). Surgery was performed in 48 with SAP (19 had elective biliary surgery and 29 had pancreatic surgery). CONCLUSIONS: The results of this survey indicate a lack of compliance with the guidelines which regard the indications mainly for interventional endoscopy and surgery. |
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Authors:
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R Pezzilli; G Uomo; A Gabbrielli; A Zerbi; L Frulloni; P De Rai; L Castoldi; G Cavallini; V Di Carlo; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2007-06-29 |
Journal Detail:
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Title: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Volume: 39 ISSN: 1590-8658 ISO Abbreviation: Dig Liver Dis Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2007-11-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100958385 Medline TA: Dig Liver Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 838-46 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Gastroenterology, S. Orsola-Malpighi Hospital, Bologna, Italy. raffaele.pezzilli@aosp.bo.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Analgesics / therapeutic use Anti-Bacterial Agents / therapeutic use Digestive System Surgical Procedures / statistics & numerical data Female Histamine Antagonists / therapeutic use Humans Italy / epidemiology Male Middle Aged Pancreatitis / drug therapy*, epidemiology, surgery* Prospective Studies Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Anti-Bacterial Agents; 0/Histamine Antagonists |
| Comments/Corrections | |
Comment In:
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Dig Liver Dis. 2007 Sep;39(9):847-8
[PMID:
17652040
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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