Document Detail

A prospective multicenter study to evaluate the feasibility and safety of aggressive antihypertensive treatment in patients with acute intracerebral hemorrhage.
MedLine Citation:
PMID:  15665258     Owner:  NLM     Status:  MEDLINE    
The authors performed a multicenter prospective observational study to evaluate the feasibility and safety of intravenous antihypertensive protocol for acute hypertension in patients with intracerebral hemorrhage (ICH). Twenty-seven patients with ICH and acute hypertension (mean age 61.37 +/- 14.27; 10 were men) were treated to maintain the systolic blood pressure (BP) below 160 mm Hg and diastolic BP below 90 mm Hg within 24 hours of symptom onset. Neurological deterioration (defined as a decrease in initial Glasgow Coma Scale score > or = 2) was observed in 2 (7.4%) of 27 patients during treatment. Among patients who underwent follow-up computed tomography, hematoma expansion (more than 33% increase in hematoma size at 24 hours) was observed in 2 (9.1%) of 22 patients. Patients treated within 6 hours of symptom onset were more likely to be functionally independent (modified Rankin scale < or = 2) at 1 month compared with patients who were treated between 6 and 24 hours (8 of 18 versus 0 of 9,P = .03). Aggressive pharmacological treatment of acute hypertension in patients with ICH can be initiated early with a low rate of neurological deterioration and hematoma expansion.
Adnan I Qureshi; Yousef M Mohammad; Abutaher M Yahia; Jose I Suarez; Amir M Siddiqui; Jawad F Kirmani; M Fareed K Suri; James Kolb; Osama O Zaidat
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Journal of intensive care medicine     Volume:  20     ISSN:  0885-0666     ISO Abbreviation:  J Intensive Care Med     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2005-01-24     Completed Date:  2005-04-14     Revised Date:  2006-10-13    
Medline Journal Info:
Nlm Unique ID:  8610344     Medline TA:  J Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-42     Citation Subset:  IM    
Zennat Qureshi Stroke Research Center, Department of Neurology and Neurosciences, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103-2425, USA.
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MeSH Terms
Acute Disease
Analysis of Variance
Antihypertensive Agents / therapeutic use*
Cerebral Hemorrhage / complications,  drug therapy*,  radiography
Cerebrovascular Circulation / drug effects
Feasibility Studies
Hypertension / drug therapy*,  etiology
Middle Aged
Prospective Studies
Tomography, X-Ray Computed
Reg. No./Substance:
0/Antihypertensive Agents

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