| A prospective longitudinal volumetric MRI study of superior temporal gyrus gray matter and amygdala-hippocampal complex in chronic schizophrenia. | |
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MedLine Citation:
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PMID: 19524408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A progressive post-onset decrease in gray matter volume 1.5 years after first hospitalization in schizophrenia has been shown in superior temporal gyrus (STG). However, it is still controversial whether progressive volume reduction occurs in chronic schizophrenia in the STG and amygdala-hippocampal complex (AHC), structures found to be abnormal in chronic schizophrenia. These structures were measured at two time points in 16 chronic schizophrenia patients and 20 normal comparison subjects using manual tracing with high spatial resolution magnetic resonance imaging (MRI). Average interscan interval was 3.1 years for schizophrenia patients and 1.4 years for healthy comparison subjects. Cross-sectional comparisons showed smaller relative volumes in schizophrenia compared with controls in posterior STG and AHC. An ANCOVA with interscan interval as a covariate showed there was no statistically significant progression of volume reduction in either the STG or AHC in the schizophrenia group compared with normal subjects. In the schizophrenia group, volume change in the left anterior AHC significantly correlated with PANSS negative symptoms. These data, and separately reported first episode data from our laboratory, suggest marked progression at the initial stage of schizophrenia, but less in chronic schizophrenia. |
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Authors:
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Takeshi Yoshida; Robert W McCarley; Motoaki Nakamura; KangUk Lee; Min-Seong Koo; Sylvain Bouix; Dean F Salisbury; Lindsay Morra; Martha E Shenton; Margaret A Niznikiewicz |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-06-13 |
Journal Detail:
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Title: Schizophrenia research Volume: 113 ISSN: 1573-2509 ISO Abbreviation: Schizophr. Res. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-14 Completed Date: 2009-10-12 Revised Date: 2011-03-16 |
Medline Journal Info:
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Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 84-94 Citation Subset: IM |
Affiliation:
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Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School, Brockton, MA 02301, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amygdala / pathology* Brain Mapping Chronic Disease Hippocampus / pathology* Humans Image Processing, Computer-Assisted Longitudinal Studies Magnetic Resonance Imaging / methods* Male Middle Aged Neural Pathways / pathology, physiology Psychiatric Status Rating Scales Schizophrenia / pathology* Statistics as Topic Temporal Lobe / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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K02 MH 01110/MH/NIMH NIH HHS; K02 MH001110-10/MH/NIMH NIH HHS; P50MH080272/MH/NIMH NIH HHS; R01 MH 052807/MH/NIMH NIH HHS; R01 MH 40799/MH/NIMH NIH HHS; R01 MH 50747/MH/NIMH NIH HHS; R01 MH082918-03/MH/NIMH NIH HHS; R03 MH 078036/MH/NIMH NIH HHS |
| Comments/Corrections | |
Comment In:
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Schizophr Res. 2010 Mar;117(1):99-100
[PMID:
20079612
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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