Document Detail


A prospective evaluation of the treatment of primary or metastatic liver carcinoma with hepatic arterial infusion chemotherapy.
MedLine Citation:
PMID:  8695158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of hepatic arterial infusion chemotherapy (HAICT) in the treatment of primary or metastatic liver carcinoma was evaluated in 37 patients. The infusions were administered through a catheter that was placed in the hepatic artery, either surgically or by percutaneous puncture of the femoral artery. A complete response was observed in four patients. A partial response was observed in six patients and a minor response in another six. In nine patients the disease had stabilized, while a progression of the disease had developed in 12 patients. After a mean of 4.7 cycles per patient, the response rate (complete, partial and minor responses) was 43.2% and median survival 12.0 months. Seventeen Grade III toxicities were observed in a total of 174 cycles, but none of them were fatal. HAICT has demonstrated a successful palliation with minimal toxicity in patients with unresectable liver carcinoma.
Authors:
S Cakmakli; S Ersöz; M Karaayvaz; A R Arat
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  35     ISSN:  0284-186X     ISO Abbreviation:  Acta Oncol     Publication Date:  1996  
Date Detail:
Created Date:  1996-09-03     Completed Date:  1996-09-03     Revised Date:  2009-05-12    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  441-4     Citation Subset:  IM    
Affiliation:
Department of Surgical Oncology, faculty of Medicine, University of Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antibiotics, Antineoplastic / administration & dosage,  adverse effects
Antimetabolites, Antineoplastic / administration & dosage,  adverse effects
Antineoplastic Agents / administration & dosage,  adverse effects
Antineoplastic Combined Chemotherapy Protocols / administration & dosage,  adverse effects,  therapeutic use*
Carcinoma / drug therapy*
Catheterization, Peripheral / instrumentation
Cisplatin / administration & dosage,  adverse effects
Disease Progression
Doxorubicin / administration & dosage,  adverse effects
Drug Administration Schedule
Evaluation Studies as Topic
Female
Fluorouracil / administration & dosage,  adverse effects
Hepatic Artery
Humans
Infusions, Intra-Arterial / instrumentation
Liver Neoplasms / drug therapy*,  secondary
Male
Middle Aged
Mitomycin / administration & dosage,  adverse effects
Palliative Care
Prospective Studies
Remission Induction
Survival Rate
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Antimetabolites, Antineoplastic; 0/Antineoplastic Agents; 15663-27-1/Cisplatin; 23214-92-8/Doxorubicin; 50-07-7/Mitomycin; 51-21-8/Fluorouracil

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