Document Detail

A prospective evaluation of primary genital herpes simplex virus type 2 infections acquired during pregnancy.
MedLine Citation:
PMID:  2164656     Owner:  NLM     Status:  MEDLINE    
In order to study the epidemiology of herpes simplex type 2 (HSV-2) infections during pregnancy, we used an enzyme immunoassay to detect type-specific antibodies to HSV-2 glycoprotein G in serial blood samples obtained from a cohort of 1891 pregnant women. Blood samples obtained at about 17 and 32 weeks of gestation and at the time of delivery were assessed for antibody to HSV-2 glycoprotein G in order to evaluate the prevalence of past infections with HSV-2 and the rate of acquisition of HSV-2 infection during pregnancy. Three hundred eleven pregnant women (16.5%) were found to have had past infections with HSV-2. Four of the 1580 women who were initially seronegative developed antibodies to HSV-2 during pregnancy. The annualized rate of acquisition of HSV-2 infection in pregnant women was 0.58%. Three of four women had asymptomatic primary infections; all of the women had preexisting HSV-1 immunity. None of the women or their infants experienced any adverse consequences of gestational herpes. Based upon our very limited number of observations to date, asymptomatic primary episodes occurring in women with previous HSV-1 immunity may be of less consequence to the fetus and neonate than symptomatic true primary HSV-2 infections.
F D Boucher; L L Yasukawa; R N Bronzan; P A Hensleigh; A M Arvin; C G Prober
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  9     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-08-23     Completed Date:  1990-08-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  499-504     Citation Subset:  IM    
Department of Pediatrics, Stanford University School of Medicine, CA.
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MeSH Terms
Age Factors
Antibodies, Viral / analysis*
California / epidemiology
Evaluation Studies as Topic
Gestational Age
Herpes Genitalis / blood,  epidemiology,  transmission*
Immunity, Innate
Infant, Newborn
Middle Aged
Pregnancy Complications, Infectious* / blood,  epidemiology
Prospective Studies
Simplexvirus / classification*,  isolation & purification
Viral Envelope Proteins / immunology*
Grant Support
Reg. No./Substance:
0/Antibodies, Viral; 0/Viral Envelope Proteins; 0/glycoprotein G, herpes simplex virus type 2

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