Document Detail

A prospective evaluation of 200 upper endoscopies performed in Alaska Native persons.
MedLine Citation:
PMID:  17515254     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To characterize the nature and prevalence of disease in Alaska Native patients referred for evaluation of upper gastrointestinal signs and symptoms. STUDY DESIGN: Cross-sectional. METHODS: Two hundred consecutive Alaska Native patients referred to a statewide tertiary center were prospectively evaluated. A standardized data collection form documenting EGD findings was utilized. Routine biopsies of the antrum and fundus were taken on all patients. Additional tissue was obtained from any areas of clinical concern. RESULTS: Among 200 patients who underwent EGD during the study period, 130 (65%) tested H. pylori-positive on histology. Among 173 patients with histologic evidence of gastritis, 114 (66%) tested H. pylori-positive on histology. Chronic gastritis (87%), gastric ulcer (GU 12%), duodenal ulcer (DU 3%) and gastric cancer (2%) were the predominant findings. The GU:DU ratio was 4:1, the inverse of that reported in the general U.S. population. CONCLUSIONS: Alaska Native patients referred for upper endoscopy have a high rate of H. pylori infection with predominantly gastric manifestations of disease and a GU:DU ratio, which is the inverse of what is typically seen in the U.S. and other developed countries. The high prevalence of H. pylori in Alaska Native patients resembles prevalence patterns reported from developing countries and may be linked to a rate of gastric cancer that is over three times that found in the U.S. population at large.
Frank Sacco; Michael G Bruce; Brian J McMahon; Dana Bruden
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of circumpolar health     Volume:  66     ISSN:  1239-9736     ISO Abbreviation:  Int J Circumpolar Health     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-05-22     Completed Date:  2007-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9713056     Medline TA:  Int J Circumpolar Health     Country:  Finland    
Other Details:
Languages:  eng     Pagination:  144-52     Citation Subset:  IM    
Department of Surgery, Alaska Native Medical Center, Anchorage 99508, USA.
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MeSH Terms
Aged, 80 and over
Alaska / epidemiology
Cross-Sectional Studies
Duodenal Ulcer / diagnosis,  ethnology
Endoscopy, Gastrointestinal / utilization
Gastritis / diagnosis,  ethnology
Gastrointestinal Diseases / diagnosis,  ethnology*,  pathology
Helicobacter Infections / diagnosis,  ethnology*
Helicobacter pylori / isolation & purification*
Inuits / statistics & numerical data*
Middle Aged
Prospective Studies
Stomach Neoplasms / diagnosis,  ethnology
Stomach Ulcer / diagnosis,  ethnology
Upper Gastrointestinal Tract / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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