Document Detail

A prospective critical evaluation of in vitro thyroid function tests.
MedLine Citation:
PMID:  3766208     Owner:  NLM     Status:  MEDLINE    
A number of 2 325 serum samples from a population of in- and outpatients were collected during a six-month period in order to evaluate the usefulness of various thyroid function tests in the clinical laboratory routine. The samples were analysed with the following thyroid function tests: total triiodothyronine (T3) (TT3), total thyroxine (T4) (TT4), free T3 index (FT3I), free T4 index (FT4I) and thyrotropin (TSH). One to two years after the primary evaluation, a follow-up was performed and the final diagnoses were checked in the patients' records. The values of these parameters in the diagnosis of hyperthyroidism were: FT3I greater than FT4I greater than TT3 greater than TT4. The corresponding results in the diagnosis of hypothyroidism were: TSH greater than FT4I greater than FT3I = TT3. No single test could detect both hyper- and hypothyroidism effectively. The only one-step strategy for thyroid evaluation in patients without apparent clinical signs of hyper- or hypothyroidism would therefore be the combined determination of T3 and TSH. The study also showed distinct differences between the reference values of the healthy population and patients without thyroid disorders.
U B Ericsson; J I Thorell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  220     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1986  
Date Detail:
Created Date:  1986-11-10     Completed Date:  1986-11-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  47-56     Citation Subset:  IM    
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MeSH Terms
Evaluation Studies as Topic
Follow-Up Studies
Hyperthyroidism / diagnosis
Hypothyroidism / diagnosis
Middle Aged
Prospective Studies
Thyroid Function Tests / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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