| A prospective comparative study of narrow-band imaging, chromoendoscopy, and conventional colonoscopy in the diagnosis of colorectal neoplasia. | |
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MedLine Citation:
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PMID: 17005766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Discrimination between neoplastic and non-neoplastic lesions is crucial in colorectal cancer screening. Application of narrow-band imaging (NBI) in colonoscopy visualises mucosal vascular networks in neoplastic lesions and may improve diagnostic accuracy. AIM: To compare the diagnostic efficacy of NBI in differentiating neoplastic from non-neoplastic colorectal lesions with diagnostic efficacies of standard modalities, conventional colonoscopy, and chromoendoscopy. METHODS: In this prospective study, 180 colorectal lesions from 133 patients were observed with conventional colonoscopy, and under low-magnification and high-magnification NBI and chromoendoscopy. Lesions were resected for histopathological analysis. Endoscopic images were stored electronically and randomly allocated to two readers for evaluation. Sensitivity, specificity and diagnostic accuracy of each endoscopic modality were assessed by reference to histopathology. RESULTS: NBI and chromoendoscopy scored better under high magnification than under low magnification in comparison with conventional colonoscopy. The diagnostic accuracy of NBI with low or high magnification was significantly higher than that of conventional colonoscopy (low magnification: p = 0.0434 for reader 1 and p = 0.004 for reader 2; high magnification: p<0.001 for both readers) and was comparable to that of chromoendoscopy. CONCLUSION: Both low-magnification and high-magnification NBI were capable of distinguishing neoplastic from non-neoplastic colorectal lesions; the diagnostic accuracy of NBI was better than that of conventional colonoscopy and equivalent to that of chromoendoscopy. The role of NBI in screening colonoscopy needs further evaluation. |
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Authors:
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Han-Mo Chiu; Chi-Yang Chang; Chien-Chuan Chen; Yi-Chia Lee; Ming-Shiang Wu; Jaw-Town Lin; Chia-Tung Shun; Hsiu-Po Wang |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article Date: 2006-09-27 |
Journal Detail:
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Title: Gut Volume: 56 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-06 Completed Date: 2007-04-04 Revised Date: 2010-09-14 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: England |
Other Details:
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Languages: eng Pagination: 373-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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diagnosis Adult Aged Aged, 80 and over Colonic Polyps / diagnosis Colonoscopy / methods Colorectal Neoplasms / diagnosis* Coloring Agents Diagnosis, Differential Epidemiologic Methods Female Humans Image Processing, Computer-Assisted / methods Indigotindisulfonate Sodium / diagnostic use Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 860-22-0/Indigotindisulfonate Sodium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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