Document Detail


A prospective cohort study of microvascular decompression and Gamma Knife surgery in patients with trigeminal neuralgia.
MedLine Citation:
PMID:  19123904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECT: The aim of this study was to analyze 1 surgeon's 4-year experience with microvascular decompression ([MVD], 36 patients) and Gamma Knife surgery ([GKS], 44 patients) in 80 consecutive patients with trigeminal neuralgia (TN). METHODS: The authors conducted a prospective cohort study from March 1999 to December 2003 with an independent clinical assessment of the results and serial patient satisfaction surveys. All patients completed a 2004 patient satisfaction survey (0.5-5 years postoperative), and 70% of surviving patients completed the same survey in 2007 (3.9-8.5 years postoperative). Follow-up was undertaken in 100% of the patients (mean 3.4 +/- 2.14 years, range 0.17-8.5 years). RESULTS: Respective initial and latest follow-up raw pain-free rates were 100 and 80.6% for MVD and 77.3 and 45.5% for GKS. The median time to the maximal benefit after GKS was 4 weeks (range 1 week-6 months). Respective initial, 2-, and 5-year actuarial pain-free rates were 100, 88, and 80% for MVD and 78, 50, and 33% for GKS (p = 0.0002). The relative risk of losing a pain-free status by 5 years posttreatment was 3.35 for patients in the GKS group compared with the MVD group. Initial and 5-year actuarial rates for >or= 50% pain relief after GKS were 100 and 80%, respectively. The respective rates of permanent mild and severe sensory loss were 5.6 and 0% for patients in the MVD group, as opposed to 6.8 and 2.3% for patients in the GKS group. Anesthesia dolorosa did not occur during the study. Both procedures enjoyed a high degree of early patient satisfaction (95-100%). Microvascular decompression maintained the same rate of patient satisfaction, but satisfaction with GKS decreased to 75% as pain control waned. Twenty-three patients (29%) died of causes unrelated to the TN or the surgical intervention during the follow-up, and their pain status was known at the time of death. Statistically significant intergroup differences for the MVD versus GKS cohorts were age (median 54 years, range 36-70 years vs median 74 years, range 48-92 years, respectively), preoperative symptom duration (median 2.58 years, range 0.33-15 years vs median 7.5, range 0.6-40 years, respectively), and the presence of major comorbidities (2.8 vs 58.3%, respectively). CONCLUSIONS: In this nonrandomized prospective cohort trial of selected patients with potentially relevant intergroup differences, MVD was significantly superior to GKS in achieving and maintaining a pain-free status in those with TN and provided similar early and superior longer-term patient satisfaction rates compared with those for GKS. The complications of wound cerebrospinal fluid leakage, hearing loss, and persistent diplopia (1 case each in the MVD group) were not seen after GKS.
Authors:
Mark E Linskey; Vaneerat Ratanatharathorn; Jose Peñagaricano
Related Documents :
8416244 - The effect of embolization with n-butyl cyanoacrylate prior to surgical resection of ce...
10753984 - Stereotactic computed tomographic-guided aspiration and thrombolysis of intracerebral h...
15696264 - Gamma knife radiosurgery in skull base meningiomas: a possible relationship between som...
18053854 - Surgical treatment of dumbbell-shaped neurinomas: report of an experience with 57 cases...
2794924 - Arthrodesis of the nonrheumatoid wrist.
9930424 - Multivariate analysis of survival after malfunctioning biological and mechanical prosth...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  109 Suppl     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-06     Completed Date:  2009-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  160-72     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurological Surgery, University of California, Irvine Medical Center, Orange, California 92868, USA. mlinskey@uci.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Cohort Studies
Decompression, Surgical*
Female
Humans
Male
Microsurgery*
Middle Aged
Patient Satisfaction
Radiosurgery*
Rhizotomy / methods*
Treatment Outcome
Trigeminal Neuralgia / diagnosis,  etiology,  surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gamma Knife surgery for trigeminal pain caused by benign brain tumors.
Next Document:  Clinical outcomes after Gamma Knife surgery for idiopathic trigeminal neuralgia: review of 76 consec...