Document Detail

A prospective 2-year study of 75 patients with adult-onset septic arthritis.
MedLine Citation:
PMID:  11157138     Owner:  NLM     Status:  MEDLINE    
AIMS AND METHODS: To assess the clinical features of septic arthritis and characterize therapeutic strategies and outcome in a prospective study of 75 patients selected by positive synovial fluid culture.
RESULTS: Underlying joint disease was present in 46 patients, 25 of whom had rheumatoid arthritis and 15 osteoarthritis. Eleven patients were i.v. drug abusers. Fifty-six per cent of cases involved the knee, 15% involved two or more joints, and staphylococci and streptococci were cultured in >90%. Seventy-eight per cent of patients lived in areas of high social deprivation. Fever was present in 64% and the white cell count (WCC) was normal in 38%. The C-reactive protein was elevated in 98%. Leg ulcers were present in 11% of all patients but in 38% of patients who died (P<0.006). Median duration of antibiotic therapy was 15 days i.v. with subsequent oral treatment for 21 days. Thirty-seven per cent of cases required surgical intervention. Mortality was 11%. A raised WCC at presentation (P<0.02) and the development of abnormal renal function (P<0.015) were predictors of poor prognosis.
M N Gupta; R D Sturrock; M Field
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  40     ISSN:  1462-0324     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-03-15     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  24-30     Citation Subset:  AIM; IM    
Centre for Rheumatic Diseases, University Department of Medicine, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK.
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MeSH Terms
Age of Onset
Anti-Bacterial Agents / therapeutic use
Antirheumatic Agents / therapeutic use*
Arthritis, Infectious / drug therapy*,  epidemiology,  microbiology,  physiopathology,  surgery
Bacterial Infections / drug therapy
Immunosuppressive Agents / therapeutic use*
Middle Aged
Prospective Studies
Risk Factors
Social Class
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antirheumatic Agents; 0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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