Document Detail


pros-Methylimidazoleacetic acid in cerebrospinal fluid of patients with chronic schizophrenia: relationships to ratings of symptoms, ventricular brain ratios, and rates of urine excretion.
MedLine Citation:
PMID:  8889284     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concentrations of pros-methylimidazoleacetic acid (p-MIAA) were measured in cerebrospinal fluid of 30 patients with chronic schizophrenia. Levels of p-MIAA correlated negatively with mean scores of the Psychiatric Symptom Assessment Scale for positive symptoms (r = -0.48), but not negative symptoms, and with ventricular brain ratios (r = -0.48). Patients with abnormal ventricular enlargements had much lower concentrations of p-MIAA than those with normal ventricles. These results suggest that processes that reduce accumulation of p-MIAA in CSF may be associated with increased severity of symptoms among patients with chronic schizophrenia.
Authors:
G D Prell; J P Green; J K Khandelwal; R J Wyatt; W B Lawson; A C Jaeger; C A Kaufmann; D G Kirch
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical neuropharmacology     Volume:  19     ISSN:  0362-5664     ISO Abbreviation:  Clin Neuropharmacol     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-02-04     Completed Date:  1997-02-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7607910     Medline TA:  Clin Neuropharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  415-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, New York 10029-6574, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cerebral Ventricles / metabolism*
Chronic Disease
Female
Humans
Imidazoles / cerebrospinal fluid*
Male
Middle Aged
Psychiatric Status Rating Scales*
Regression Analysis
Schizophrenia / cerebrospinal fluid*,  urine*
Urine
Grant Support
ID/Acronym/Agency:
MH-31805/MH/NIMH NIH HHS; NS-28012/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Imidazoles; 2625-49-2/methylimidazoleacetic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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