Document Detail

The (pro)renin receptor: a new kid in town.
MedLine Citation:
PMID:  17868788     Owner:  NLM     Status:  MEDLINE    
Renin inhibitors are now available in therapeutic doses and it is accepted that they decrease blood pressure as efficiently as the classic inhibitors of the renin-angiotensin system (RAS): angiotensin converting enzyme inhibitors and angiotensin II-receptor blockers (ARBs). One major issue will be to know how, beyond the normalization of blood pressure, renin inhibitors (RIs) will compare with angiotensin converting enzyme inhibitors and ARBs for their ability to protect the organs against the tissue damage associated with overactivation of the RAS. The mechanism(s) of tissue protection may involve the inhibition of a direct cellular effect of renin and prorenin mediated by the (pro)renin receptor ([P]RR). This review updates the recent findings on (P)RR; its role in hypertension, cardiac fibrosis, diabetic nephropathy, and retinopathy; and the effects of a putative (P)RR antagonist.
Geneviève Nguyen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in nephrology     Volume:  27     ISSN:  0270-9295     ISO Abbreviation:  Semin. Nephrol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8110298     Medline TA:  Semin Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  519-23     Citation Subset:  IM    
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 36, and Collège de France, Unit of Experimental Medicine, Paris, France.
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MeSH Terms
Blood Pressure / physiology
Gene Expression
Hypertension / genetics,  metabolism*,  physiopathology
Receptors, Cell Surface / genetics,  metabolism*
Renin / metabolism*
Reg. No./Substance:
0/Receptors, Cell Surface; 0/prorenin receptor; EC

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