| A proprietary topical preparation containing EGCG-stearate and glycerin with inhibitory effects on herpes simplex virus: case study. | |
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MedLine Citation:
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PMID: 22583482 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The effects of a proprietary topical formulation containing EGCG-stearate in 100% glycerin USP were studied in two volunteer patients with recurrent herpes simplex type (HSV) 1. Application during early onset (prodromal stage) in a patient with herpes labialis prevented lesion progression. In a second patient with herpetic stomatitis, application of the formula during a later stage (inflammation stage) led to a remarkably shortened duration of symptoms. In contrast, a third patient provided 100% glycerin USP only as placebo failed to demonstrate any therapeutic or preventive effect against lesion occurrence or duration of lesion and healing time. These results suggest that this proprietary topical preparation could be used effectively to prevent and treat HSV-induced symptoms, and warrants further clinical investigation. |
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Authors:
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Man Zhao; Jinyan Jiang; Rongrong Zheng; Henna Pearl; Douglas Dickinson; Baiping Fu; Stephen Hsu |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-11 |
Journal Detail:
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Title: Inflammation & allergy drug targets Volume: - ISSN: 2212-4055 ISO Abbreviation: Inflamm Allergy Drug Targets Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101266886 Medline TA: Inflamm Allergy Drug Targets Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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AD1443 College of Dental Medicine, Georgia Health Sciences University, 1120 15th Street Augusta, GA 30912, USA. shsu@georgiahealth.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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