Document Detail


A proposed neuropathological basis for learning disabilities in children born prematurely.
MedLine Citation:
PMID:  6852386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study aimed at providing understanding of the etiology and mechanisms responsible for the learning and behavioral disabilities in the increasing numbers of survivors of neonatal intensive care units who develop MBD/LD-type (minimal brain dysfunction, learning disabilities) complications. The brains of 16 premature infants who died within the first month of life were studied by microscopic examination. Significant neuropathological findings in gray-matter and white-matter were found in many areas, including both superficial cortical and deep basal brain structures. These lesions are postulated to be precursors to later LD and MBD syndromes in infants who survive, such that similar lesions of varying severity correlate with varying degrees of brain dysfunction. Premature infants who survive are known from other studies to be high-risk candidates for LD- and MBD- type developmental disabilities.
Authors:
P W Fuller; R D Guthrie; E C Alvord
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  25     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  214-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Brain / pathology*
Humans
Infant, Newborn
Infant, Premature*
Learning Disorders / complications*
Necrosis
Periaqueductal Gray / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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