| A proposal of simple calculation (ERI calculator) to predict the early response to TNF-α blockers therapy in rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 21110028 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Increasing evidence has been accumulated for treating rheumatoid arthritis (RA) with TNF-α blocking agents. The formulation and definition of an early indicator of patient's reactivity during therapy may be extremely simplified by a mathematical model of clinical response. We analyzed the most significant clinical and laboratory parameters of response of 35 homogeneous patients (30 women, 5 men mean age ± SD: 52.31 ± 12.30 years) treated with adalimumab 40 mg every 2 weeks associated with methotrexate (MTX) 10-15 mg/week and with a stable dosage of steroids for 30 weeks. The over time trend of the studied parameters showed a linear response, which has allowed the realization of a simple mathematical model. The formula derived from this mathematical model was then applied and therefore validated in a group of 121 patients previously treated with several anti-TNF-alpha agents for at least 6 months. We drafted a mathematical model (early response indicator, ERI) that, by using a simple calculation, allows us to identify a high percentage of responder patients after only 2 weeks of treatment. ERI identified a high percentage (88%) of patients responding after only 2 weeks, as was confirmed at weeks 30; the use of ERI calculation after 6 weeks increases the proportion of responding patients to 92% with a percentage of false negatives of only 12%. ERI could be a useful tool to early differentiate the responder from the non-responder patients. |
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Authors:
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Laura Bazzichi; Paolo Rossi; Camillo Giacomelli; Francesca De Feo; Francesca Bobbio-Pallavicini; Alessandra Rossi; Chiara Baldini; Arianna Consensi; Marica Doveri; Claudia Bonino; Maurizio Mazzantini; Alessandra Della Rossa; Carlomaurizio Montecucco; Stefano Bombardieri |
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Publication Detail:
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Type: Journal Article Date: 2010-11-26 |
Journal Detail:
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Title: Rheumatology international Volume: 32 ISSN: 1437-160X ISO Abbreviation: Rheumatol. Int. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 349-56 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Division of Rheumatology, University of Pisa, Via Roma, 67, 56100, Pisa, Italy, l.bazzichi@int.med.unipi.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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