| The proper ratio of FtsZ to FtsA is required for cell division to occur in Escherichia coli. | |
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MedLine Citation:
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PMID: 1400163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interactions among cell division genes in Escherichia coli were investigated by examining the effect on cell division of increasing the expression of the ftsZ, ftsA, or ftsQ genes. We determined that cell division was quite sensitive to the levels of FtsZ and FtsA but much less so to FtsQ. Inhibition of cell division due to an increase in FtsZ could be suppressed by an increase in FtsA. Inhibition of cell division due to increased FtsA could be suppressed by an increase in FtsZ. In addition, although wild-type strains were relatively insensitive to overexpression of ftsQ, we observed that cell division was sensitized to ftsQ overexpression in ftsI, ftsA, and ftsZ mutants. Among these, the ftsI mutant was the most sensitive. These results suggest that these gene products may interact and that the proper ratio of FtsZ to FtsA is critical for cell division to occur. |
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Authors:
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K Dai; J Lutkenhaus |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of bacteriology Volume: 174 ISSN: 0021-9193 ISO Abbreviation: J. Bacteriol. Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-10-29 Completed Date: 1992-10-29 Revised Date: 2010-09-07 |
Medline Journal Info:
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Nlm Unique ID: 2985120R Medline TA: J Bacteriol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 6145-51 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City 66103. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Proteins
/
genetics,
metabolism* Cell Division / genetics, physiology Cytoskeletal Proteins* Escherichia coli / cytology, genetics, growth & development* Escherichia coli Proteins* Membrane Proteins / genetics, metabolism Mutation Transcription, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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GM29674/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Cytoskeletal Proteins; 0/Escherichia coli Proteins; 0/FtsA protein, Bacteria; 0/FtsA protein, E coli; 0/FtsQ protein, E coli; 0/FtsZ protein, Bacteria; 0/Membrane Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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