Document Detail

The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxide nanoparticles.
MedLine Citation:
PMID:  19359036     Owner:  NLM     Status:  MEDLINE    
Superparamagnetic iron oxide (SPIO) nanoparticles are very useful in cell imaging; meanwhile, however, biosafety concerns associated with their use, especially on therapeutic stem cells, have arisen. Most studies of biosafety issues focus on whether the nanoparticles have deleterious effects. Here, we report that Ferucarbotran, an ionic SPIO, is not toxic to human mesenchymal stem cells (hMSCs) under the conditions of these experiments but instead increases cell growth. Ferucarbotran-promoted cell growth is due to its ability to diminish intracellular H2O2 through intrinsic peroxidase-like activity. Also, Ferucarbotran can accelerate cell cycle progression, which may be mediated by the free iron (Fe) released from lysosomal degradation and involves the alteration of Fe on the expression of the protein regulators of the cell cycle.
Dong-Ming Huang; Jong-Kai Hsiao; Ying-Chun Chen; Li-Ying Chien; Ming Yao; Yin-Kai Chen; Bor-Sheng Ko; Szu-Chun Hsu; Lin-Ai Tai; Hui-Ying Cheng; Shih-Wei Wang; Chung-Shi Yang; Yao-Chang Chen
Related Documents :
11562436 - Synergistic toxicity of iron and arachidonic acid in hepg2 cells overexpressing cyp2e1.
2043266 - Comparison of transferrin receptors, iron content and isoferritin profile in normal and...
8814446 - The effects of ascorbic acid and iron co-supplementation on the proliferation of 3t3 fi...
9568816 - Effect of desferrioxamine and deferiprone (l1) on the proliferation of mg-63 bone cells...
8978466 - Supporting cells as phagocytes in the olfactory epithelium after bulbectomy.
24842606 - Neurotransmitter transporter family including slc6a6 and slc6a13 contributes to the 5-a...
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-08
Journal Detail:
Title:  Biomaterials     Volume:  30     ISSN:  1878-5905     ISO Abbreviation:  Biomaterials     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-05-26     Completed Date:  2009-07-28     Revised Date:  2013-04-11    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  3645-51     Citation Subset:  IM    
Center for Nanomedicine Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli 350, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Cycle / physiology
Cell Proliferation / drug effects*
Contrast Media / chemistry,  pharmacology
Ferric Compounds / chemistry,  pharmacology*
Hydrogen Peroxide / metabolism
Iron / chemistry,  pharmacology*
Magnetic Resonance Imaging
Magnetite Nanoparticles
Materials Testing
Mesenchymal Stromal Cells / cytology,  drug effects*,  physiology*
Nanoparticles / chemistry*
Oxidants / metabolism
Oxides / chemistry,  pharmacology*
Peroxidases / metabolism
Reg. No./Substance:
0/Contrast Media; 0/Ferric Compounds; 0/Magnetite Nanoparticles; 0/Oxidants; 0/Oxides; 1309-37-1/ferric oxide; 1317-61-9/Ferumoxytol; 7439-89-6/Iron; 7722-84-1/Hydrogen Peroxide; 9004-54-0/Dextrans; EC 1.11.1.-/Peroxidases; G6N3J05W84/ferumoxides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Public policy for the poor? A randomised assessment of the Mexican universal health insurance progra...
Next Document:  The promotion of the vascularization of decalcified bone matrix in vivo by rabbit bone marrow mononu...