Document Detail


The promoting role of a tumour-secreted chemorepellent in self-metastatic tumour progression.
MedLine Citation:
PMID:  20929852     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
It has been proposed that cancer cells, in particular glioma tumour cells, secrete a chemorepellent factor that guides cell migration away from the tumour, facilitating migration and invasion. We present a hybrid continuous-discrete mathematical model of tumour growth and the chemotropism phenomenon to show that such a chemorepellent factor can also act as a promoter of self-metastases, a mechanism for tumour expansion we have previously shown can explain several essential kinetic dependencies of tumour growth. A sufficient criterion for this expansion was found to be the passive migration of peripheral cancer stem and non-stem cells away from the main tumour mass, where migrating cancer stem cells form new clusters. We show here how the introduction of an active repellent trait serves to accelerate peripheral migration and thus, by the self-metastases principle, accelerate tumour growth. These results provide a mechanistic basis for the proposal that chemorepellent action in gliomas may underlie their rapid growth.
Authors:
Heiko Enderling; Lynn Hlatky; Philip Hahnfeldt
Publication Detail:
Type:  Journal Article     Date:  2010-10-06
Journal Detail:
Title:  Mathematical medicine and biology : a journal of the IMA     Volume:  29     ISSN:  1477-8602     ISO Abbreviation:  Math Med Biol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101182345     Medline TA:  Math Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  21-9     Citation Subset:  IM    
Affiliation:
Center of Cancer Systems Biology, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, 736 Cambridge Street, Boston, MA 02135, USA.
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