Document Detail

Citrulline/malate promotes aerobic energy production in human exercising muscle.
MedLine Citation:
PMID:  12145119     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous studies have shown an antiasthenic effect of citrulline/malate (CM) but the mechanism of action at the muscular level remains unknown. OBJECTIVE: To investigate the effects of CM supplementation on muscle energetics. METHODS: Eighteen men complaining of fatigue but with no documented disease were included in the study. A rest-exercise (finger flexions)-recovery protocol was performed twice before (D-7 and D0), three times during (D3, D8, D15), and once after (D22) 15 days of oral supplementation with 6 g/day CM. Metabolism of the flexor digitorum superficialis was analysed by (31)P magnetic resonance spectroscopy at 4.7 T. RESULTS: Metabolic variables measured twice before CM ingestion showed no differences, indicating good reproducibility of measurements and no learning effect from repeating the exercise protocol. CM ingestion resulted in a significant reduction in the sensation of fatigue, a 34% increase in the rate of oxidative ATP production during exercise, and a 20% increase in the rate of phosphocreatine recovery after exercise, indicating a larger contribution of oxidative ATP synthesis to energy production. Considering subjects individually and variables characterising aerobic function, extrema were measured after either eight or 15 days of treatment, indicating chronological heterogeneity of treatment induced changes. One way analysis of variance confirmed improved aerobic function, which may be the result of an enhanced malate supply activating ATP production from the tricarboxylic acid cycle through anaplerotic reactions. CONCLUSION: The changes in muscle metabolism produced by CM treatment indicate that CM may promote aerobic energy production.
D Bendahan; J P Mattei; B Ghattas; S Confort-Gouny; M E Le Guern; P J Cozzone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of sports medicine     Volume:  36     ISSN:  0306-3674     ISO Abbreviation:  Br J Sports Med     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-29     Completed Date:  2002-11-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0432520     Medline TA:  Br J Sports Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  282-9     Citation Subset:  IM    
Centre de Résonance Magnétique Biologique et Médicale, UMR CNRS 6612, Faculté de Médecine de la Timone, 27 Boulevard Jean Moulin, 13005 Marseille, France.
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MeSH Terms
Analysis of Variance
Citrulline / analogs & derivatives*,  pharmacology*
Fourier Analysis
Linear Models
Magnetic Resonance Spectroscopy
Malates / pharmacology*
Muscle Fatigue / drug effects*
Muscle, Skeletal / metabolism*
Reg. No./Substance:
0/Malates; 372-75-8/Citrulline; 54940-97-5/citrulline malate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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