Document Detail

4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene in children with systemic meningococcaemia.
MedLine Citation:
PMID:  15843979     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: Our data show a correlation between the 4G/4G genotype in the plasminogen activator inhibitor-1 gene and poor outcome in children with meningococcal infection. In addition, 4G homozygous patients were prone to develop sepsis. We found no influence of the plasminogen activator inhibitor-1 polymorphism on the susceptibility to invasive meningococcal infection.
Gotho Geishofer; Alexander Binder; Martin Müller; Bettina Zöhrer; Bernhard Resch; Wilhelm Müller; Jörg Faber; Adam Finn; Georg Endler; Christine Mannhalter; Werner Zenz;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2005-04-21
Journal Detail:
Title:  European journal of pediatrics     Volume:  164     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-26     Completed Date:  2006-02-21     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  486-90     Citation Subset:  IM    
Department of General Paediatrics, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria.
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MeSH Terms
Austria / epidemiology
Child, Preschool
Gene Frequency
Germany / epidemiology
Great Britain / epidemiology
Italy / epidemiology
Meningococcal Infections / blood,  diagnosis,  genetics*,  mortality
Odds Ratio
Plasminogen Activator Inhibitor 1 / genetics*
Polymorphism, Genetic*
Promoter Regions, Genetic / genetics*
Prospective Studies
Switzerland / epidemiology
Reg. No./Substance:
0/Plasminogen Activator Inhibitor 1; 73-40-5/Guanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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