Document Detail

A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers.
MedLine Citation:
PMID:  10867119     Owner:  NLM     Status:  MEDLINE    
Concentrations of monoamine metabolites (MM) in lumbar cerebrospinal fluid (CSF) have been used extensively as indirect estimates of monoamine turnover in the brain. We investigated possible relationships between a putative functional promoter polymorphism in the monoamine oxidase A (MAOA) gene and CSF concentrations of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy volunteers (n=88). Among women (n=37), those carrying at least one copy of the alleles associated with more efficient transcription displayed higher concentrations of HVA (p=0.01) and 5-HIAA (p=0.01). In men (n=51), however, there was a tendency in the opposite direction. The results suggest that MAOA genotypes may participate differentially in the regulation of dopamine and serotonin turnover rates under presumed steady state in the central nervous system. The results should be interpreted with caution until replicated because of the limited sample size.
E G Jönsson; N Norton; J P Gustavsson; L Oreland; M J Owen; G C Sedvall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of psychiatric research     Volume:  34     ISSN:  0022-3956     ISO Abbreviation:  J Psychiatr Res     Publication Date:    2000 May-Jun
Date Detail:
Created Date:  2000-08-24     Completed Date:  2000-08-24     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  239-44     Citation Subset:  IM    
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MeSH Terms
Biogenic Monoamines / cerebrospinal fluid*
Gene Expression Profiling / methods
Homovanillic Acid / cerebrospinal fluid
Hydroxyindoleacetic Acid / cerebrospinal fluid
Methoxyhydroxyphenylglycol / cerebrospinal fluid
Middle Aged
Minisatellite Repeats / genetics*
Monoamine Oxidase / genetics*,  metabolism*
Polymorphism, Genetic*
Promoter Regions, Genetic / genetics*
Sex Factors
Grant Support
44814//PHS HHS; G9309834//Medical Research Council
Reg. No./Substance:
0/Biogenic Monoamines; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid; EC Oxidase; X77S6GMS36/Homovanillic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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