Document Detail


A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers.
MedLine Citation:
PMID:  10867119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concentrations of monoamine metabolites (MM) in lumbar cerebrospinal fluid (CSF) have been used extensively as indirect estimates of monoamine turnover in the brain. We investigated possible relationships between a putative functional promoter polymorphism in the monoamine oxidase A (MAOA) gene and CSF concentrations of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy volunteers (n=88). Among women (n=37), those carrying at least one copy of the alleles associated with more efficient transcription displayed higher concentrations of HVA (p=0.01) and 5-HIAA (p=0.01). In men (n=51), however, there was a tendency in the opposite direction. The results suggest that MAOA genotypes may participate differentially in the regulation of dopamine and serotonin turnover rates under presumed steady state in the central nervous system. The results should be interpreted with caution until replicated because of the limited sample size.
Authors:
E G Jönsson; N Norton; J P Gustavsson; L Oreland; M J Owen; G C Sedvall
Related Documents :
9135059 - Distinct activation of monoaminergic pathways in chick brain in relation to auditory im...
10910589 - Excitatory and inhibitory amino acid levels in the cerebrospinal fluids of children wit...
2426539 - Dynamic characteristics of dopamine, norepinephrine and serotonin metabolism in axonal ...
6209989 - Csf neurochemistry in depressed, manic, and schizophrenic patients compared with that o...
2580329 - Decrease in dopamine, its metabolites and noradrenaline in cerebrospinal fluid of schiz...
7520379 - Association of cerebrospinal fluid deficiency of 5-methyltetrahydrofolate, but not s-ad...
2297939 - Glycosaminoglycans of the hemodialysis-associated carpal synovial amyloid and of amyloi...
17880399 - D-amino acid oxidase and serine racemase in human brain: normal distribution and altere...
23320609 - Antibacterial and antiplasmodial constituents of beilschmiedia cryptocaryoides.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of psychiatric research     Volume:  34     ISSN:  0022-3956     ISO Abbreviation:  J Psychiatr Res     Publication Date:    2000 May-Jun
Date Detail:
Created Date:  2000-08-24     Completed Date:  2000-08-24     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  239-44     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Biogenic Monoamines / cerebrospinal fluid*
Female
Gene Expression Profiling / methods
Genotype
Homovanillic Acid / cerebrospinal fluid
Humans
Hydroxyindoleacetic Acid / cerebrospinal fluid
Male
Methoxyhydroxyphenylglycol / cerebrospinal fluid
Middle Aged
Minisatellite Repeats / genetics*
Monoamine Oxidase / genetics*,  metabolism*
Polymorphism, Genetic*
Promoter Regions, Genetic / genetics*
Sex Factors
Grant Support
ID/Acronym/Agency:
44814//PHS HHS; G9309834//Medical Research Council
Chemical
Reg. No./Substance:
0/Biogenic Monoamines; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid; EC 1.4.3.4/Monoamine Oxidase; X77S6GMS36/Homovanillic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Changes in directed attention and short-term memory in depression.
Next Document:  Habituation of the auditory evoked field component N100m in male patients with schizophrenia.