Document Detail


A promising anticancer and antimalarial component from the leaves of Bidens pilosa.
MedLine Citation:
PMID:  19031368     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bidens pilosa is used in folk medicine for various applications due to the presence of polyacetylenes, flavonoids, terpenoids, phenylpropanoids and others. Bioactivity-guided fractionation of different extracts of B. pilosa leaf showed potential in vitro anticancer and antimalarial activity and led to the identification of a potential marker compound, phenyl-1,3,5-heptatriyne. Erythrocyte osmotic fragility experiments revealed the various extracts as well as the marker component's toxicity profiles on normal blood cells.
Authors:
Priyanka Kumari; Kanak Misra; Brijesh Singh Sisodia; Uzma Faridi; Suchita Srivastava; Suiab Luqman; Mahendra Pandurang Darokar; Arvind Singh Negi; Madan Mohan Gupta; Subhash Chandra Singh; Jonnala Kotesh Kumar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-24
Journal Detail:
Title:  Planta medica     Volume:  75     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  59-61     Citation Subset:  IM    
Affiliation:
Analytical Chemistry Division, Central Institute of Medicinal and Aromatic Plants (CIMAP), Council of Scientific and Industrial Research (CSIR), Lucknow, India.
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MeSH Terms
Descriptor/Qualifier:
Alkynes / chemistry,  isolation & purification,  pharmacology*
Animals
Antimalarials / chemistry,  isolation & purification,  pharmacology*
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification,  pharmacology*
Bidens / chemistry*
Cell Line, Tumor
Drugs, Chinese Herbal / chemistry,  isolation & purification,  pharmacology*
Erythrocytes / drug effects
Humans
Osmotic Fragility / drug effects
Plant Leaves / chemistry
Plasmodium falciparum / drug effects
Chemical
Reg. No./Substance:
0/Alkynes; 0/Antimalarials; 0/Antineoplastic Agents, Phytogenic; 0/Drugs, Chinese Herbal; 0/plant extract, Bidens pilosa; 4300-27-0/phenylheptatriyne

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