Document Detail

The prolonged P(300) latency in recently detoxified alcohol-dependent patients is related to activation of the inflammatory response system.
MedLine Citation:
PMID:  11174047     Owner:  NLM     Status:  MEDLINE    
The aims of this study were to examine the late components of the auditory event-related potentials (AERPs), i.e. N(100), P(200) and P(300), in recently detoxified alcohol-dependent patients compared to normal controls and to investigate whether there is a relationship between alterations in these AERPs and signs of activation of the inflammatory response system (IRS). The study subjects consisted of 14 healthy volunteers and 14 recently detoxified alcohol-dependent patients. All subjects performed a two-tone auditory discrimination task, using a standard "oddball" paradigm. The alcohol-dependent patients had their blood sampled to examine IRS markers, such as erythrocyte sedimentation rate (ESR), serum copper concentrations and the number of leukocytes. The P(300) latency was significantly greater in recently detoxified alcohol-dependent patients than in normal controls. There were significant correlations between the P(300) latency and the ESR (r = 0.84, p = 0.009), serum copper concentrations (r = 0.73, p = 0.01) and number of monocytes (r = 0.71, p = 0.006). It is concluded that the P(300) latency is prolonged in detoxified, chronic alcohol-dependent patients and is positively related to indicators of IRS activation. It is hypothesized that activation of the IRS may play a role in the delayed P(300) latency in recently detoxified, alcohol-dependent patients.
M Maes; D van West; D Nuyten; H Neels; N De Vos; S De Bruyne; J Degroote
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropsychobiology     Volume:  43     ISSN:  0302-282X     ISO Abbreviation:  Neuropsychobiology     Publication Date:  2001  
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7512895     Medline TA:  Neuropsychobiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  63-9     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Department of Psychiatry and Neuropsychology, University Hospital of Maastricht, Postbus 5800, NL-6202 AZ Maastricht, The Netherlands.
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MeSH Terms
Alcoholism / blood*,  enzymology,  immunology,  therapy
Blood Sedimentation*
Case-Control Studies
Copper / blood*
Event-Related Potentials, P300
Evoked Potentials, Auditory*
Leukocyte Count
Liver / enzymology*
Reg. No./Substance:

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