Document Detail

A proline-to-histidine mutation in POU1F1 is associated with production traits in dairy cattle.
MedLine Citation:
PMID:  18557974     Owner:  NLM     Status:  MEDLINE    
POU class 1 homeobox 1 (POU1F1) is a member of the tissue-specific POU-containing transcription factor family. The expression of POU1F1 in mammalian pituitary gland controls the transcription of the genes encoding growth hormone, prolactin (PRL) and the subunits of thyroid-stimulating hormone. In addition, some genes in the JAK/STAT signalling pathway downstream of POU1F1 have been shown to be associated with different production traits in dairy cattle. To investigate whether the POU1F1 gene is associated with economically important traits in dairy cattle, a pooled DNA sequencing approach was used to identify single nucleotide polymorphisms (SNPs) in the gene. An SNP in exon 3 of POU1F1 that changes a proline to a histidine was identified. A total of 2141 individuals from two North American Holstein cattle resource populations were genotyped for this SNP using a modified PCR-RFLP method. Statistical analyses revealed significant association of POU1F1 variants with milk yield and productive life, which makes POU1F1 a possible candidate for marker-assisted selection in dairy cattle breeding programmes.
W Huang; C Maltecca; H Khatib
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-06-28
Journal Detail:
Title:  Animal genetics     Volume:  39     ISSN:  1365-2052     ISO Abbreviation:  Anim. Genet.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-08     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8605704     Medline TA:  Anim Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  554-7     Citation Subset:  IM    
Department of Dairy Science, University of Wisconsin-Madison, Madison, WI 53706, USA.
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MeSH Terms
Amino Acid Substitution
Cattle / genetics*
Histidine / metabolism
Milk / metabolism*
Point Mutation*
Proline / metabolism
Transcription Factor Pit-1 / genetics*
Reg. No./Substance:
0/Transcription Factor Pit-1; 147-85-3/Proline; 71-00-1/Histidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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