Document Detail

The proliferative capacity of the cells of the avian Harderian gland.
MedLine Citation:
PMID:  3258255     Owner:  NLM     Status:  MEDLINE    
The largest concentration of plasmacytic cells within avian lymphomyeloid tissue appears in the Harderian Gland (HG). Mature plasma cells were the least frequent cell at day old and the most frequent by 5-weeks of age. Failure of phytohemagglutinin-M to stimulate blasting of HG cells may reflect the low number of T cells in the HG. On the other hand, the uptake of tritiated thymidine by HG cells after short term culture in complete medium was significantly greater than that of splenic cells. The proliferating cells were the plasmablast, and mature plasma cell. Our data demonstrated that labeled B-cells, administered intravenously to 2- or 6-week old syngeneic or allogeneic chickens, did not migrate to the HG. The origin of HG plasma cells may be B-cells which entered prior to 2 weeks of age or the HG may possess a special microenvironment which allowed stem cell differentiation. The maintenance of a high concentration of plasma cells in the HG in the presence of low levels of B-cells may reflect the long-lived nature of the resident B-cell and/or the inherent proliferative capacity of the HG plasmacytic cell.
M Gallego; B Glick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Developmental and comparative immunology     Volume:  12     ISSN:  0145-305X     ISO Abbreviation:  Dev. Comp. Immunol.     Publication Date:  1988  
Date Detail:
Created Date:  1988-05-10     Completed Date:  1988-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708205     Medline TA:  Dev Comp Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  157-66     Citation Subset:  IM    
Poultry Science Department, Clemson University, SC 29634.
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MeSH Terms
B-Lymphocytes / cytology,  immunology
Cell Division
Cell Movement
Chickens / anatomy & histology,  immunology*
Harderian Gland / cytology,  immunology*
Lacrimal Apparatus / immunology*
Lymphocyte Activation
Phytohemagglutinins / pharmacology
Plasma Cells / cytology,  immunology*
T-Lymphocytes / cytology,  immunology
Reg. No./Substance:
0/Phytohemagglutinins; 0/phytohemagglutinin-M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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