Document Detail

Is prolactin the cardinal calciotropic maternal hormone?
MedLine Citation:
PMID:  20304671     Owner:  NLM     Status:  MEDLINE    
To produce offspring, mothers require a large amount of calcium for fetal growth and milk production. Increased calcium demand leads to enhanced intestinal calcium absorption and stockpiling of bone calcium in pregnancy prior to demineralization in lactation. These coordinated events must be carefully organized by calciotropic hormone(s), but the classical hormones, namely 1,25-dihydroxyvitamin D(3), parathyroid hormone and calcitonin, do not appear to be responsible. Plasma prolactin (PRL) levels are elevated during pregnancy and, in view of the presence of PRL receptors in gut, bone and mammary glands, as well as recent evidence of the stimulatory effects of PRL on intestinal calcium transport, bone resorption and mammary calcium secretion, we postulate that PRL is the cardinal calciotropic hormone during pregnancy and lactation.
Narattaphol Charoenphandhu; Kannikar Wongdee; Nateetip Krishnamra
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-20
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  21     ISSN:  1879-3061     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-05     Completed Date:  2010-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  395-401     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
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MeSH Terms
Bone Resorption / metabolism
Bone and Bones / metabolism
Calcium / metabolism*
Calcium, Dietary / metabolism*
Infant, Newborn
Intestinal Absorption
Intestines / metabolism
Ion Transport
Prolactin / metabolism*
Signal Transduction
Reg. No./Substance:
0/Calcium, Dietary; 7440-70-2/Calcium; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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