Document Detail


The progression potential of peritoneal dissemination nodules from gastrointestinal tumors.
MedLine Citation:
PMID:  22808619     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
It is necessary to examine the characteristics of the dissemination nodules to establish a therapeutic strategy for peritoneal dissemination from digestive malignancy. Ki-67 expression as a proliferation marker in peritoneal dissemination nodules was investigated. The subjects were 15 patients with gastrointestinal cancers who underwent resection of the primary tumor and disseminated nodules. The expression of Ki-67 in both primary tumor and peritoneal dissemination nodule from each patient was evaluated by immunohistochemistry. Ki-67 labeling index in the original tumor was higher than that in the disseminated nodule in 13 of 15 patients (P < 0.0001). The mean value of Ki-67 labeling index was 42.2% in the 15 original tumors and 18.7% in the 15 disseminated nodules. Proliferative activity in the disseminated nodules was lower than that in the primary tumors. Further examination about characteristics of cancer dissemination is needed to treat patients with peritoneal metastasis.
Authors:
Hayato Yamauchi; Toshinaga Suto; Wakako Kigure; Hiroki Morita; Toshihide Kato; Reina Yajima; Takaaki Fujii; Satoru Yamaguchi; Soichi Tsutsumi; Takayuki Asao; Hiroyuki Kuwano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International surgery     Volume:  96     ISSN:  0020-8868     ISO Abbreviation:  Int Surg     Publication Date:    2011 Oct-Dec
Date Detail:
Created Date:  2012-07-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0043524     Medline TA:  Int Surg     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  352-7     Citation Subset:  IM    
Affiliation:
Department of General Surgical Science (Surgery I), Gunma University, Graduate School of Medicine, Gunma, Japan. hyamauti@showa.gunma-u.ac.jp
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