| The progression potential of peritoneal dissemination nodules from gastrointestinal tumors. | |
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MedLine Citation:
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PMID: 22808619 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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It is necessary to examine the characteristics of the dissemination nodules to establish a therapeutic strategy for peritoneal dissemination from digestive malignancy. Ki-67 expression as a proliferation marker in peritoneal dissemination nodules was investigated. The subjects were 15 patients with gastrointestinal cancers who underwent resection of the primary tumor and disseminated nodules. The expression of Ki-67 in both primary tumor and peritoneal dissemination nodule from each patient was evaluated by immunohistochemistry. Ki-67 labeling index in the original tumor was higher than that in the disseminated nodule in 13 of 15 patients (P < 0.0001). The mean value of Ki-67 labeling index was 42.2% in the 15 original tumors and 18.7% in the 15 disseminated nodules. Proliferative activity in the disseminated nodules was lower than that in the primary tumors. Further examination about characteristics of cancer dissemination is needed to treat patients with peritoneal metastasis. |
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Authors:
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Hayato Yamauchi; Toshinaga Suto; Wakako Kigure; Hiroki Morita; Toshihide Kato; Reina Yajima; Takaaki Fujii; Satoru Yamaguchi; Soichi Tsutsumi; Takayuki Asao; Hiroyuki Kuwano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International surgery Volume: 96 ISSN: 0020-8868 ISO Abbreviation: Int Surg Publication Date: 2011 Oct-Dec |
Date Detail:
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Created Date: 2012-07-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0043524 Medline TA: Int Surg Country: Italy |
Other Details:
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Languages: eng Pagination: 352-7 Citation Subset: IM |
Affiliation:
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Department of General Surgical Science (Surgery I), Gunma University, Graduate School of Medicine, Gunma, Japan. hyamauti@showa.gunma-u.ac.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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