Document Detail


A prognostic view on the application of individualized genomics in Parkinson's disease.
MedLine Citation:
PMID:  23504498     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Parkinson's disease is a common age-related progressive neurodegenerative disorder. Over the last 15 years advances have been made in our understanding of the etiology of the disease, with the greatest insights perhaps coming from genetic studies. The identification of a number of genes that harbor pathogenic mutations causing Parkinson's disease have on the whole driven the development of disease model systems and nominated a number of therapeutic targets. As we move towards an era of personalized medicine, genetic determinants will become even more crucial for accurate diagnosis, and assessing prognosis and outcomes. The individual genomic profile and risk assessments will in the long-term determine clinical trial participation, treatment plans and therapeutic dosing. Herein we discuss the status of genetics in Parkinson's disease and how these factors may affect the patient care in the future.
Authors:
Owen A Ross
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-12
Journal Detail:
Title:  Current genetic medicine reports     Volume:  1     ISSN:  2167-4876     ISO Abbreviation:  Curr Genet Med Rep     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101601192     Medline TA:  Curr Genet Med Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  52-57     Citation Subset:  -    
Affiliation:
Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
P50 NS072187/NS/NINDS NIH HHS; R01 NS078086/NS/NINDS NIH HHS

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