Document Detail

The prognostic value and significance of preclinical abortions in in vitro fertilization-embryo transfer programs.
MedLine Citation:
PMID:  1712324     Owner:  NLM     Status:  MEDLINE    
Preclinical abortions occur in natural conceptions as well as in in vitro fertilization-embryo transfer (IVF-ET) cycles. Nevertheless, although known, this entity is ill defined. OBJECTIVE: The purpose of this study was to propose a classification of these pregnancies on the basis of pathophysiological evidence and to evaluate their future clinical impact. DESIGN: Of 970 IVF-ET cycles, 114 cycles (11.7%) terminated in preclinical abortions. Abortions were divided according to peak beta human chorionic gonadotropin (beta-hCG) values into chemical abortions (52%) occurring 2 weeks after ET with beta-hCG values not higher than 21 mIU/mL and peri-implantation abortions (47%) terminating spontaneously 4 weeks after ET; the latter had higher beta-hCG values for a longer period of time but without any sonographic evidence of gestational sac. No woman in the two groups needed curettage. RESULTS: After a chemical abortion, the pregnancy outcome had better ongoing pregnancy rates (24.7%) in comparison with the 17% achieved in the total IVF-ET cycles. CONCLUSIONS: It is concluded that these two groups most probably have different pathophysiological backgrounds and concomitantly different future clinical impacts.
T Levy; D Dicker; J Ashkenazi; D Feldberg; M Shelef; J A Goldman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  56     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-08-09     Completed Date:  1991-08-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  71-4     Citation Subset:  IM    
Sherman Fertility Institute, Department of Obstetrics-Gynecology, Golda Meir Medical Center (Hasharon Hospital), Petah-Tikva, Israel.
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MeSH Terms
Abortion, Spontaneous / blood*
Chorionic Gonadotropin / blood
Chorionic Gonadotropin, beta Subunit, Human
Embryo Implantation
Embryo Transfer*
Fertilization in Vitro*
Infertility, Female / therapy
Peptide Fragments / blood
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Peptide Fragments

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