Document Detail

The prognostic value of long-term ambulatory electroencephalography in antiepileptic drug reduction in adults with learning disability and epilepsy in long-term remission.
MedLine Citation:
PMID:  18602025     Owner:  NLM     Status:  MEDLINE    
We determined the additional yield of ambulatory over routine electroencephalography recordings in predicting seizure recurrence after antiepileptic drug (AED) withdrawal in 15 adult patients with various epilepsy syndromes who had been seizure free for at least 3 years (median=10 years). Eleven of 15 patients (74%) relapsed during or after AED withdrawal. All six patients with epileptiform discharges on ambulatory electroencephalography prior to AED withdrawal relapsed, compared with five of nine patients without epileptiform discharges. Ambulatory electroencephalography significantly increases the yield in detecting epileptiform discharges (n=6) compared with routine electroencephalography (n=1). A negative electroencephalographic finding is only a poor predictor of seizure freedom following AED withdrawal. On clinical grounds, our data suggest that patients with epilepsy, learning disability, and other known risk factors (history of abnormal EEGs and frequent seizures, abnormal MRI) are at great risk of seizure relapse during AED taper, irrespective of very long periods of seizure freedom.
Matthias J Koepp; Fiona Farrell; Jayne Collins; Shelagh Smith
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-21
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  13     ISSN:  1525-5069     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-08     Completed Date:  2009-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  474-7     Citation Subset:  IM    
Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, National Society for Epilepsy MRI Unit, Queen Square, Chesham Lane, Chalfont St. Peter, Gerrards Cross, Bucks, London SL9 0RJ, UK.
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MeSH Terms
Aged, 80 and over
Anticonvulsants / administration & dosage
Electrocardiography, Ambulatory / methods*
Epilepsy / drug therapy*,  physiopathology*
Learning Disorders / drug therapy*,  physiopathology*
Longitudinal Studies
Middle Aged
Recurrence / prevention & control
Reg. No./Substance:

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