| The prognostic value of haemodynamic parameters in the recovery phase of an exercise test. The Finnish Cardiovascular Study. | |
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MedLine Citation:
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PMID: 18509348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We tested the hypothesis that the change from the peak to recovery values of systolic arterial pressure (SAP recovery) and rate-pressure product (RPP recovery) can be used to predict all-cause and cardiovascular mortality, as well as sudden cardiac death (SCD) in patients referred to a clinical exercise stress test. As a part of the Finnish Cardiovascular Study (FINCAVAS), consecutive patients (n=2029; mean age+/-SD=57+/-13 years; 1290 men and 739 women) with a clinically indicated exercise test using a bicycle ergometer were included in the present study. Capacities of attenuated SAP recovery, RPP recovery and heart rate recovery (HRR) to stratify the risk of death were estimated. During a follow-up (mean+/-s.d.) of 47+/-13 months, 122 patients died; 58 of the deaths were cardiovascular and 33 were SCD. In Cox regression analysis after adjustment for the peak level of the variable under assessment, age, sex, use of beta-blockers, previous myocardial infarction and other common coronary risk factors, the hazard ratio of the continuous variable RPP recovery (in units 1000 mm Hg x b.p.m.) was 0.85 (95% CI: 0.73-0.98) for SCD, 0.87 (0.78-0.97) for cardiovascular mortality, and 0.87 (0.81 to 0.94) for all-cause mortality. SAP recovery was not a predictor of mortality. The relative risks of having HRR below 18 b.p.m., a widely used cutoff point, were as follows: for SCD 1.28 (0.59-2.81, ns), for cardiovascular mortality 2.39 (1.34-4.26) and for all-cause mortality 2.40 (1.61-3.58). In conclusion, as a readily available parameter, RPP recovery is a promising candidate for a prognostic marker. |
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Authors:
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T Nieminen; J Leino; J Maanoja; K Nikus; J Viik; T Lehtimäki; T Kööbi; R Lehtinen; K Niemelä; V Turjanmaa; M Kähönen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-29 |
Journal Detail:
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Title: Journal of human hypertension Volume: 22 ISSN: 0950-9240 ISO Abbreviation: J Hum Hypertens Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-17 Completed Date: 2008-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 537-43 Citation Subset: IM |
Affiliation:
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Department of Pharmacological Sciences, Medical School, University of Tampere, Tampere, Finland. tuomo.nieminen@iki.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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physiology* Cardiovascular Diseases / mortality, physiopathology* Cause of Death / trends Exercise / physiology* Exercise Test / methods* Female Finland / epidemiology Humans Male Middle Aged Prognosis Proportional Hazards Models Recovery of Function / physiology* Retrospective Studies Risk Factors Survival Rate / trends |
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