Document Detail

The prognostic value of early transcranial Doppler ultrasound following cardiopulmonary resuscitation.
MedLine Citation:
PMID:  17169697     Owner:  NLM     Status:  MEDLINE    
The aim of the presented study was to estimate the prognostic value of transcranial Doppler sonography (TCD) for the prediction of clinical outcome of patients after cardiopulmonary resuscitation (CPR) on the basis of the measured flow velocity changes in the basal cerebral arteries. Thirty-nine patients (27 men, 12 women) aged 66 +/- 15 y (+/-SD) who had undergone CPR were involved. Serial TCD examinations of the intracranial arteries were performed 1.5, 4, 8, 16, 24 and 72 h after CPR. Plasma neuron specific enolase (NSE), ventilation parameters (pH, paO(2), paCO(2)) and hemodynamic parameters were registered. Seventeen patients (group 1) survived with moderate or without neurologic deficits. Twenty-two patients (group 2) either died (n = 21) within 9 +/- 14 days or remained in vegetative state (n = 1). NSE levels ranged from 9 to 29 microg/L in group 1 and from 22 to 1242 microg/L in group 2 (p < 0.05). Four and 72 h after CPR, peak systolic flow velocities in the middle cerebral artery (MCA) were significantly higher in group 1 than in group 2 (p < 0.05). Twenty-four h after CPR, peak systolic and diastolic flow velocities in the ACA and PCA were also significantly higher in group 1 than in group 2 (p < 0.05). At this time, patients of group 2 showed significantly higher resistance index-values (RI = (sys-dia)/sys) in the anterior cerebral artery (ACA) and the posterior cerebral artery (PCA) (p < 0.05). A high correlation between peak systolic blood flow velocity in the MCA and systemic systolic blood pressure was observed in group 2 early 4 to 16 h after CPR (r = +0.52 to + 0.81, p < 0.05), while there was no such correlation in group 1. Using serial TCD examinations, patients with severely disabling or fatal outcome could be identified within the first 24 h. Besides established clinical and laboratory parameters, postanoxic myoclonus and NSE, serial TCD examinations following CPR may be helpful to predict the clinical outcome, but further studies with a larger number of patients are necessary to approve this hypothesis.
Tiemo Wessels; Judith U Harrer; Christian Jacke; Uwe Janssens; Christof Klötzsch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  32     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-15     Completed Date:  2007-03-19     Revised Date:  2008-04-30    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1845-51     Citation Subset:  IM    
Department of Neurology, Aachen University Hospital Aachen, Germany.
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MeSH Terms
Aged, 80 and over
Blood Flow Velocity / physiology
Blood Pressure / physiology
Brain Ischemia / physiopathology,  ultrasonography
Carbon Dioxide / physiology
Cardiopulmonary Resuscitation*
Cerebral Arteries / physiopathology,  ultrasonography*
Cerebrovascular Circulation / physiology
Heart Diseases / physiopathology,  therapy,  ultrasonography
Middle Aged
Myoclonus / physiopathology,  ultrasonography
Phosphopyruvate Hydratase / blood
Ultrasonography, Doppler, Transcranial / methods*
Vascular Resistance / physiology
Reg. No./Substance:
124-38-9/Carbon Dioxide; EC Hydratase
Comment In:
Ultrasound Med Biol. 2008 Jan;34(1):166   [PMID:  17854982 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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