Document Detail

The prognostic value of cardiopulmonary exercise testing in idiopathic pulmonary fibrosis.
MedLine Citation:
PMID:  19074597     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is characterized by progressive dyspnea, impaired gas exchange, and ultimate mortality.
OBJECTIVES: To test the hypothesis that maximal oxygen uptake during cardiopulmonary exercise testing at baseline and with short-term longitudinal measures would predict mortality in patients with idiopathic pulmonary fibrosis.
METHODS: Data from 117 patients with IPF and longitudinal cardiopulmonary exercise tests were examined retrospectively. Survival was calculated from the date of the first cardiopulmonary exercise test.
MEASUREMENTS AND MAIN RESULTS: Patients with baseline maximal oxygen uptake less than 8.3 ml/kg/min had an increased risk of death (n = 8; hazard ratio, 3.24; 95% confidence interval, 1.10-9.56; P = 0.03) after adjusting for age, gender, smoking status, baseline forced vital capacity, and baseline diffusion capacity for carbon monoxide. We were unable to define a unit change in maximal oxygen uptake that predicted survival in our cohort.
CONCLUSIONS: We conclude that a threshold maximal oxygen uptake of 8.3 ml/kg/min during cardiopulmonary exercise testing at baseline adds prognostic information for patients with IPF.
Charlene D Fell; Lyrica Xiaohong Liu; Caroline Motika; Ella A Kazerooni; Barry H Gross; William D Travis; Thomas V Colby; Susan Murray; Galen B Toews; Fernando J Martinez; Kevin R Flaherty
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-12-12
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  179     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-23     Completed Date:  2009-04-01     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  402-7     Citation Subset:  AIM; IM    
Division of Respiratory Medicine, University of Calgary, Calgary, Canada.
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MeSH Terms
Exercise Test*
Exercise Tolerance
Kaplan-Meier Estimate
Logistic Models
Middle Aged
Oxygen / metabolism
Oxygen Consumption / physiology
Predictive Value of Tests
Proportional Hazards Models
Pulmonary Fibrosis / diagnosis*,  metabolism*
Retrospective Studies
Smoking / adverse effects
Grant Support
1 K23 HL68713/HL/NHLBI NIH HHS; 1K23 HL077719/HL/NHLBI NIH HHS; 2 K24 HL04212/HL/NHLBI NIH HHS; K24 HL004212-06/HL/NHLBI NIH HHS; K24 HL004212-07/HL/NHLBI NIH HHS; K24 HL004212-08/HL/NHLBI NIH HHS; K24 HL004212-09/HL/NHLBI NIH HHS; K24 HL004212-10/HL/NHLBI NIH HHS; P50 HL056402-019001/HL/NHLBI NIH HHS; P50 HL056402-029001/HL/NHLBI NIH HHS; P50 HL056402-039001/HL/NHLBI NIH HHS; P50 HL056402-049001/HL/NHLBI NIH HHS; P50 HL056402-059001/HL/NHLBI NIH HHS; P50 HL056402-069001/HL/NHLBI NIH HHS; P50 HL056402-079001/HL/NHLBI NIH HHS; P50 HL056402-089001/HL/NHLBI NIH HHS; P50 HL056402-099001/HL/NHLBI NIH HHS; P50 HL056402-109001/HL/NHLBI NIH HHS; P50HL-56402/HL/NHLBI NIH HHS
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