Document Detail

The prognostic value of age, gender, pregnancy and endocrine factors in multiple sclerosis.
MedLine Citation:
PMID:  11205363     Owner:  NLM     Status:  MEDLINE    
The evolution of multiple sclerosis at the time of diagnosis remains unpredictable since a reliable prognostic marker is not yet available. Nevertheless, a series of useful prognostic indicators have been singled out from epidemiological studies. Young age at onset, female gender, relapsing/remitting course, and sensitive or visual disturbances as initial symptoms are considered favourable prognostic factors. Conversely, late age at onset, male gender, progressive course, and pyramidal or cerebellar symptoms at the first episode predict an unfavourable evolution. Another prognostic indicator has been recognized in pregnancy: although the overall effect of pregnancy on short-term MS course is neutral, in the long-term it seems to protect from disease progression. Most prognostic indicators seem to act through the neuro-endocrine-immune network, modulating the immune response in the context of the Th1/Th2 paradigm.
M Zaffaroni; A Ghezzi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  21     ISSN:  1590-1874     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2000  
Date Detail:
Created Date:  2001-02-02     Completed Date:  2001-04-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  S857-60     Citation Subset:  IM    
Multiple Sclerosis Center, Gallarate Hospital, University of Milan, VA, Italy.
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MeSH Terms
Age of Onset
Endocrine System / physiopathology*
Multiple Sclerosis / physiopathology*
Pregnancy Complications*
Risk Factors
Sex Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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