Document Detail


The prognostic value of acute phase reactants in patients with neuroblastoma.
MedLine Citation:
PMID:  71194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As part of a more extensive study of the immune response in children with neuroblastoma, serum immunoglobulin and alpha-glycoprotein levels were measured in 58 patients. Twenty-nine children were studied at diagnosis, 18 at some time during the first 2 years of treatment, and 11 who were apparently cured after treatment had been completed. No correlation was found between the levels of IgG, IgA, and IgM and the clinical status of the patient. The acute phase reactants (alpha-1-antitrypsin, haptoglobin, C3 component of complement and orosomucoid) varied with the disease status. Twenty-seven of the 29 patients had elevated levels at the time of diagnosis. Alpha-1-antitrypsin and haptoglobin were the two proteins that most accurately reflection the clinical status; C3 component of complement was not infrequently normal when the disease was active; and orosomucoid was sometimes raised in patients apparently in remission. Serial measurement of alpha-1-antitrypsin and haptoglobin could provide a useful means of detecting early relapse in patients responding to treatment.
Authors:
J Gerson; A E Evans; F S Rosen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer     Volume:  40     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1977-11-30     Completed Date:  1977-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1655-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alpha-Globulins / analysis*
Child
Child, Preschool
Complement C3 / analysis
Humans
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Immunoglobulins / analysis*
Neuroblastoma / immunology*
Prognosis
Chemical
Reg. No./Substance:
0/Alpha-Globulins; 0/Complement C3; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Immunoglobulins

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