Document Detail


The prognostic value of acute phase reactants in patients with neuroblastoma.
MedLine Citation:
PMID:  71194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As part of a more extensive study of the immune response in children with neuroblastoma, serum immunoglobulin and alpha-glycoprotein levels were measured in 58 patients. Twenty-nine children were studied at diagnosis, 18 at some time during the first 2 years of treatment, and 11 who were apparently cured after treatment had been completed. No correlation was found between the levels of IgG, IgA, and IgM and the clinical status of the patient. The acute phase reactants (alpha-1-antitrypsin, haptoglobin, C3 component of complement and orosomucoid) varied with the disease status. Twenty-seven of the 29 patients had elevated levels at the time of diagnosis. Alpha-1-antitrypsin and haptoglobin were the two proteins that most accurately reflection the clinical status; C3 component of complement was not infrequently normal when the disease was active; and orosomucoid was sometimes raised in patients apparently in remission. Serial measurement of alpha-1-antitrypsin and haptoglobin could provide a useful means of detecting early relapse in patients responding to treatment.
Authors:
J Gerson; A E Evans; F S Rosen
Related Documents :
6681124 - Immunologic abnormalities in idiopathic raynaud's phenomenon.
6213254 - Involvement of immune mechanisms in the pathogenesis of rosacea.
15621574 - High levels of autoantibodies against drug-metabolizing enzymes in sla/lp-positive aih-...
17067434 - Anti-saccharomyces cerevisiae antibodies in behçet's disease--a familial study.
24910654 - Can dental pulp calcification predict the risk of ischemic cardiovascular disease?
15832164 - The pediatric outcomes data collection instrument (podci) and functional assessment of ...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer     Volume:  40     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1977-11-30     Completed Date:  1977-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1655-8     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alpha-Globulins / analysis*
Child
Child, Preschool
Complement C3 / analysis
Humans
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Immunoglobulins / analysis*
Neuroblastoma / immunology*
Prognosis
Chemical
Reg. No./Substance:
0/Alpha-Globulins; 0/Complement C3; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Immunoglobulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Radiation therapy of carcinoma of gallbladder and biliary tract.
Next Document:  Multicentric dermal-type cylindromas of the parotid glands in a patient with florid turban tumor.