| The prognostic value of S-phase fraction in preoperative radiotherapy of rectal cancer. | |
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MedLine Citation:
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PMID: 11115599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to analyze the flow cytometric S-phase fraction (SPF) in rectal tumors before and after preoperative radiotherapy (15x2 Gy) and to compare the findings to the clinical outcome. Archival specimens from 84 cases, treated from 1980 to 1988 with S-phase data and complete follow-up were reviewed. There was no significant correlation between SPF and clinicopathological factors. The median SPF for the 26 diploid tumors before irradiation was 6.6%+/-3.1, compared to a significantly higher median for the 58 preirradiated aneuploid tumors (20.3%+/-6.1; p<0.0001). With a median follow-up of 6 years, there was a significant difference in the number of recurrences for aneuploid tumors with a pretreatment SPF < and >20.3 (51.7% vs. 20.7%; p=0.029), which also led to a significant difference in recurrence-free survival (p=0.05). For diploid tumors, a reduction in the percentage of cells in S-phase after radiation resulted in a borderline significant lower number of recurrences (p=0.06). It is concluded that pretreatment S-phase measurements may be of predictive value especially for aneuploid tumors. An alteration in SPF after radiotherapy may also be helpful in predicting outcome and planning therapy. |
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Authors:
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G Lammering; M M Taher; F Borchard; H H Gruenagel; R Porschen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Oncology reports Volume: 8 ISSN: 1021-335X ISO Abbreviation: Oncol. Rep. Publication Date: 2001 Jan-Feb |
Date Detail:
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Created Date: 2001-01-04 Completed Date: 2001-03-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: GREECE |
Other Details:
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Languages: eng Pagination: 201-6 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298-0058, USA. glammering@vcu.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aneuploidy* Biopsy Combined Modality Therapy DNA, Neoplasm / analysis Disease-Free Survival Female Flow Cytometry Follow-Up Studies Humans Life Tables Male Middle Aged Predictive Value of Tests Preoperative Care* Prognosis Radiotherapy, Adjuvant* Rectal Neoplasms / mortality, pathology*, radiotherapy, surgery S Phase* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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