Document Detail


The prognostic value of E-cadherin and the cadherin-associated molecules alpha-, beta-, gamma-catenin and p120ctn in prostate cancer specific survival: a long-term follow-up study.
MedLine Citation:
PMID:  17639504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To determine the value of loss of expression of E-cadherin and cadherin associated molecules as prognostic markers for prostate cancer patients in a long-term follow-up study. METHODS: Sixty-five prostate cancer specimens, obtained from patients with different stages of prostate cancer who underwent a radical prostatectomy or TUR-P between 1987 and 1991, were used for immunohistochemical analysis of the expression pattern of E-cadherin, alpha-, beta-, gamma-catenin and p120(ctn). Clinical records of these patients were studied for follow-up data and the prognostic value of expression of these adhesion molecules was determined by Kaplan-Meier survival analyses and multivariable proportional hazard regression analysis. RESULTS: Normal staining patterns were found in 36 cases (55.4%) for E-cadherin, 37 cases (56.9%) for alpha-catenin, 40 cases (61.5%) for beta-catenin, 25 cases (38.5%) for gamma-catenin, and 40 cases (61.5%) for p120(ctn). Overall, a strong correlation was found between the expression of E-cadherin and other cadherin-associated molecules. The 5-year survival rates for each staining were as follows: E-cadherin (normal 79.2%, aberrant 26.8%), alpha-catenin (normal 79.2%, aberrant 26.8%), beta-catenin (normal 73.1%, aberrant 27.3%), gamma-catenin (normal 86.4%, aberrant 37.1%), and p120(ctn) (normal 72.8%, aberrant 30.0%). There was a significant difference in survival between normal and aberrant expression in each staining (log rank P < 0.0001). The proportional hazard regression model including tumor stage and Gleason score revealed alpha-catenin expression as the best prognostic marker for patients with prostate cancer. CONCLUSIONS: Our data revealed a strong correlation between E-cadherin expression and other cadherin-associated molecules. Among these markers, alpha-catenin seems the best prognostic marker for prostate cancer specific survival. Larger studies are needed to confirm this result.
Authors:
I M van Oort; K Tomita; A van Bokhoven; M J G Bussemakers; L A Kiemeney; H F M Karthaus; J A Witjes; J A Schalken
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Prostate     Volume:  67     ISSN:  0270-4137     ISO Abbreviation:  Prostate     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-02     Completed Date:  2007-10-23     Revised Date:  2010-01-29    
Medline Journal Info:
Nlm Unique ID:  8101368     Medline TA:  Prostate     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1432-8     Citation Subset:  IM    
Copyright Information:
2007 Wiley-Liss, Inc
Affiliation:
Department of Urology, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Cadherins / biosynthesis*
Catenins / biosynthesis*
Cell Adhesion Molecules / biosynthesis*
Disease-Free Survival
Follow-Up Studies
Humans
Immunohistochemistry
Kaplan-Meiers Estimate
Male
Middle Aged
Multivariate Analysis
Phosphoproteins / biosynthesis*
Predictive Value of Tests
Prostatic Neoplasms / metabolism*,  pathology,  surgery
Tumor Markers, Biological / biosynthesis*
Chemical
Reg. No./Substance:
0/Cadherins; 0/Catenins; 0/Cell Adhesion Molecules; 0/Phosphoproteins; 0/Tumor Markers, Biological; 0/delta catenin

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