| The prognostic value of E-cadherin and the cadherin-associated molecules alpha-, beta-, gamma-catenin and p120ctn in prostate cancer specific survival: a long-term follow-up study. | |
| | |
MedLine Citation:
|
PMID: 17639504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To determine the value of loss of expression of E-cadherin and cadherin associated molecules as prognostic markers for prostate cancer patients in a long-term follow-up study. METHODS: Sixty-five prostate cancer specimens, obtained from patients with different stages of prostate cancer who underwent a radical prostatectomy or TUR-P between 1987 and 1991, were used for immunohistochemical analysis of the expression pattern of E-cadherin, alpha-, beta-, gamma-catenin and p120(ctn). Clinical records of these patients were studied for follow-up data and the prognostic value of expression of these adhesion molecules was determined by Kaplan-Meier survival analyses and multivariable proportional hazard regression analysis. RESULTS: Normal staining patterns were found in 36 cases (55.4%) for E-cadherin, 37 cases (56.9%) for alpha-catenin, 40 cases (61.5%) for beta-catenin, 25 cases (38.5%) for gamma-catenin, and 40 cases (61.5%) for p120(ctn). Overall, a strong correlation was found between the expression of E-cadherin and other cadherin-associated molecules. The 5-year survival rates for each staining were as follows: E-cadherin (normal 79.2%, aberrant 26.8%), alpha-catenin (normal 79.2%, aberrant 26.8%), beta-catenin (normal 73.1%, aberrant 27.3%), gamma-catenin (normal 86.4%, aberrant 37.1%), and p120(ctn) (normal 72.8%, aberrant 30.0%). There was a significant difference in survival between normal and aberrant expression in each staining (log rank P < 0.0001). The proportional hazard regression model including tumor stage and Gleason score revealed alpha-catenin expression as the best prognostic marker for patients with prostate cancer. CONCLUSIONS: Our data revealed a strong correlation between E-cadherin expression and other cadherin-associated molecules. Among these markers, alpha-catenin seems the best prognostic marker for prostate cancer specific survival. Larger studies are needed to confirm this result. |
| | |
Authors:
|
I M van Oort; K Tomita; A van Bokhoven; M J G Bussemakers; L A Kiemeney; H F M Karthaus; J A Witjes; J A Schalken |
Related Documents
:
|
11431104 - Dna demethylase is expressed in ovarian cancers and the expression correlates with deme... 12898594 - Nuclear localization of the metastasis-related protein s100a4 correlates with tumour st... 23387774 - Tissue mimicking materials for the detection of prostate cancer using shear wave elasto... 21039844 - Increased expression of ubiquitin-specific protease 22 can promote cancer progression a... 22227014 - Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53. 22422614 - Association of metals and proteasome activity in erythrocytes of prostate cancer patien... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Prostate Volume: 67 ISSN: 0270-4137 ISO Abbreviation: Prostate Publication Date: 2007 Sep |
Date Detail:
|
Created Date: 2007-08-02 Completed Date: 2007-10-23 Revised Date: 2010-01-29 |
Medline Journal Info:
|
Nlm Unique ID: 8101368 Medline TA: Prostate Country: United States |
Other Details:
|
Languages: eng Pagination: 1432-8 Citation Subset: IM |
Copyright Information:
|
2007 Wiley-Liss, Inc |
Affiliation:
|
Department of Urology, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Cadherins / biosynthesis* Catenins / biosynthesis* Cell Adhesion Molecules / biosynthesis* Disease-Free Survival Follow-Up Studies Humans Immunohistochemistry Kaplan-Meiers Estimate Male Middle Aged Multivariate Analysis Phosphoproteins / biosynthesis* Predictive Value of Tests Prostatic Neoplasms / metabolism*, pathology, surgery Tumor Markers, Biological / biosynthesis* |
| Chemical | |
Reg. No./Substance:
|
0/Cadherins; 0/Catenins; 0/Cell Adhesion Molecules; 0/Phosphoproteins; 0/Tumor Markers, Biological; 0/delta catenin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A comparative quantum chemical study of the ruthenium catalyzed olefin metathesis.
Next Document: Modelling, prediction and adaptive adjustment of recruitment in multicentre trials.