| The prognostic significance of natural killer cytotoxicity in patients with colorectal cancer. | |
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MedLine Citation:
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PMID: 3675190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluate the prognostic significance of preoperative natural killer (NK) cytotoxicity for K562 cells and its relationship to other prognostic factors in 102 patients with colorectal cancer who underwent curative resections between February 1984 and February 1985. The 18 patients who had recurrences within two years of surgery had significantly higher numbers of preoperative peripheral blood suppressor/cytotoxic and NK cells and significantly lower preoperative NK cytotoxicity than disease-free patients. Low preoperative NK cytotoxicity was predictive of recurrence independent of age, sex, hematocrit, procedure, blood loss, duration of surgery, Dukes' stage, specimen length, tumor size, tumor differentiation, and post-operative therapy. Low levels of in vitro NK-cell cytotoxicity may identify a subgroup of patients at high risk for recurrence. |
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Authors:
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P I Tartter; B Steinberg; D M Barron; G Martinelli |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of surgery (Chicago, Ill. : 1960) Volume: 122 ISSN: 0004-0010 ISO Abbreviation: Arch Surg Publication Date: 1987 Nov |
Date Detail:
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Created Date: 1987-11-27 Completed Date: 1987-11-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9716528 Medline TA: Arch Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1264-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Mount Sinai Medical Center, New York, NY 10029. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Colonic Neoplasms / immunology*, surgery Cytotoxicity, Immunologic Female Humans Killer Cells, Natural / immunology* Male Neoplasm Recurrence, Local Prognosis Rectal Neoplasms / immunology*, surgery |
| Grant Support | |
ID/Acronym/Agency:
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1 R01-CA-35558-01/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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