Document Detail

The prognostic role of left ventricular hypertrophy in patients with or without coronary artery disease.
MedLine Citation:
PMID:  1416558     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the association between echocardiographically determined left ventricular hypertrophy and mortality in patients with and without coronary artery disease. DESIGN: Cohort study with a mean follow-up period of 4 years. SETTING: An inner-city public hospital in Chicago. PATIENTS: A cohort of 785 patients, most of whom were black and had hypertension. INTERVENTIONS: Coronary arteriography for presumed coronary artery disease and echocardiography. MAIN OUTCOME MEASURE: All-cause and cardiac mortality. RESULTS: Left ventricular hypertrophy, based on left ventricular mass corrected for body surface area, was present in 194 of 381 patients (51%) with coronary artery disease and in 162 of 404 patients (40%) without coronary artery disease. Patients with left ventricular hypertrophy had worse survival than those without hypertrophy in both the group with coronary artery disease and the group without coronary artery disease. After adjustment was made for age at baseline, sex, and hypertension, the relative risk for death from any cause in patients with hypertrophy compared with patients without hypertrophy was 2.14 (95% CI, 1.24 to 3.68) among those with coronary artery disease and 4.14 (CI, 1.77 to 9.71) among those without coronary artery disease. CONCLUSIONS: Echocardiographically determined left ventricular hypertrophy is an important prognostic marker in patients with or without coronary artery disease. The effect of reversing ventricular hypertrophy in patients with and without coronary disease deserves further study.
J K Ghali; Y Liao; B Simmons; A Castaner; G Cao; R S Cooper
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of internal medicine     Volume:  117     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-11-16     Completed Date:  1992-11-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  831-6     Citation Subset:  AIM; IM    
Loyola University Stritch School of Medicine, Maywood, Illinois.
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MeSH Terms
Chi-Square Distribution
Coronary Disease / complications*,  diagnosis,  mortality
Follow-Up Studies
Heart Catheterization
Hypertension / complications
Hypertrophy, Left Ventricular / complications*,  diagnosis,  mortality
Middle Aged
Regression Analysis
Survival Analysis
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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