Document Detail


The prognostic role of the STK15 T91A polymorphism and of STK15 mRNA expression in patients with urothelial cell carcinoma.
MedLine Citation:
PMID:  17465238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The prognostic role of the STK15 T91A polymorphism and of STK15 mRNA expression was investigated in patients with urothelial cell carcinoma (UCC).
MATERIALS AND METHODS: The STK15 genotype with respect to the T91A polymorphism was assessed by restriction fragment length polymorphism in 135 patients. STK15 mRNA expression was measured in tumor tissues of 103 patients, using real-time quantitative PCR.
RESULTS: The T91A polymorphism lacked any prognostic information in our patient cohort. Interestingly though, STK15 mRNA expression was increased in invasive and high-grade tumors (p-values of 0.009 and 0.0001, respectively). Additionally, patients with superficial UCC (n = 82) who had a tumor recurrence in the first year after surgery displayed elevated STK15 mRNA expression levels (p = 0.009). Kaplan-Meier survival analysis revealed an increased risk of tumor progression for patients with Ta tumors (n = 62) and high STK15 expression (log-rank p = 0.04). Furthermore, a decreased overall (log-rank p = 0.006) and UCC-specific survival (log-rank p = 0.001) were shown for patients with elevated STK15 mRNA levels.
CONCLUSION: Patients with UCC and elevated levels of STK15 mRNA generally showed a more adverse disease course than patients with low levels. This may help in identifying patients in need of more aggressive treatment.
Authors:
Iman J Schultz; Lambertus A Kiemeney; Rian Roelofs; Yvonne Van Aarssen; Marko Babjuk; Johannes L Willems; Per-Uno Malmström; Dorine W Swinkels; J Alfred Witjes; Jacques B De Kok
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  27     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2007 Mar-Apr
Date Detail:
Created Date:  2007-04-30     Completed Date:  2007-05-10     Revised Date:  2011-07-11    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1025-30     Citation Subset:  IM    
Affiliation:
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Female
Genotype
Humans
Male
Middle Aged
Prognosis
Protein-Serine-Threonine Kinases / biosynthesis,  genetics*
RNA, Messenger / biosynthesis*,  genetics
Survival Rate
Urinary Bladder Neoplasms / enzymology*,  genetics*,  pathology
Urothelium / enzymology,  pathology
Chemical
Reg. No./Substance:
0/RNA, Messenger; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/aurora kinase

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