| The prognostic importance of a small acute decrement in kidney function in hospitalized patients: a systematic review and meta-analysis. | |
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MedLine Citation:
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PMID: 17954284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Recently, acute kidney injury defined by small changes in serum creatinine levels was associated with worse short-term outcomes; however, the precision and variability of this association was not fully explored. STUDY DESIGN: Systematic review and meta-analysis. SETTING & PARTICIPANTS: Hospitalized patients. SELECTION CRITERIA FOR STUDIES: MEDLINE and EMBASE databases were searched for observational cohort studies and randomized controlled trials published from 1990 through February 2007 that provided information for small changes in serum creatinine levels. PREDICTOR: Small acute changes in serum creatinine levels by absolute and percentage of changes in serum creatinine levels (lower threshold for increase in serum creatinine <0.5 mg/dL or <25%). OUTCOME: Short-term mortality (<or=30 days). RESULTS: Compared with controls, patients with a 10% to 24% increase in creatinine levels had a relative risk (RR) of death of 1.8 (95% confidence interval [CI], 1.3 to 2.5). By comparison, subjects with a 25% to 49% acute change in creatinine levels had an RR of death of 3.0 (95% CI, 1.6 to 5.8), and those with the largest change (>or=50%) had the greatest RR of death (RR, 6.9; 95% CI, 2.0 to 24.5). Results were similar when absolute changes in creatinine levels were considered and when pooled estimates of adjusted RR were used. LIMITATIONS: Individual patient data were unavailable; thus, only group-level data were pooled for meta-analysis. Results showed a significant degree of statistical heterogeneity that was only partially ameliorated by separating studies into subsets based on clinical setting. CONCLUSIONS: Short-term mortality and acute decreases in renal function are associated through a graded relationship such that even mild changes in serum creatinine levels portend worse outcome in a variety of clinical settings and patient-types. |
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Authors:
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Steven G Coca; Aldo J Peixoto; Amit X Garg; Harlan M Krumholz; Chirag R Parikh |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 50 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-23 Completed Date: 2007-11-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
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Languages: eng Pagination: 712-20 Citation Subset: IM |
Affiliation:
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Clinical Epidemiology Research Center, VA Connecticut Healthcare System, West Haven, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Comorbidity Creatinine / blood* Heart Failure / epidemiology* Hospitalization Humans Kidney Failure, Acute / blood*, epidemiology Kidney Function Tests Prognosis |
| Grant Support | |
ID/Acronym/Agency:
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K23-DK064689/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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