Document Detail


The prognostic difference of monoallelic versus biallelic deletion of 13q in chronic lymphocytic leukemia.
MedLine Citation:
PMID:  22139735     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Fluorescence in situ hybridization can detect genomic abnormalities in up to 80% of cases and provides prognostic information on patients with chronic lymphocytic leukemia (CLL). Although 13q deletion as the sole abnormality has been found to confer a favorable prognosis, there are little data as to whether there is a difference in prognostic value between monoallelic versus biallelic deletion of 13q.
METHODS: The authors reviewed the electronic database for patients with CLL who carried the 13q deletion as the sole abnormality and presented to The University of Texas MD Anderson Cancer Center (MDACC). Untreated patients were separated into 2 groups: those having monoallelic versus those with biallelic deletion of 13q. Using Mann-Whitney, chi-square, and Kaplan-Meier analysis, the baseline quantitative and qualitative variables for each group, along with the time from presentation to MDACC to treatment, were compared.
RESULTS: A total of 176 patients were identified; 143 patients had a monoallelic deletion of 13q, whereas 33 patients had a biallelic deletion. The only significantly different values between the groups were albumin (4.5 g/dL vs 4.4 g/dL; P = .01) and zeta-chain-associated protein kinase 70 (ZAP70) expression (1.7% vs 4.8%; P = .010). The median time from fluorescence in situ hybridization analysis to treatment in both the monoallelic and biallelic groups had not been reached (P = not significant).
CONCLUSIONS: Except for inconsequential differences in albumin and ZAP70 expression, there was no difference in the baseline characteristics between patients with CLL who had monoallelic or biallelic deletion of 13q. In addition, there was no significant difference in endpoints, including time to treatment.
Authors:
Ravin Garg; William Wierda; Alessandra Ferrajoli; Lynne Abruzzo; Sherry Pierce; Susan Lerner; Michael Keating; Susan O'Brien
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Publication Detail:
Type:  Journal Article     Date:  2011-12-02
Journal Detail:
Title:  Cancer     Volume:  118     ISSN:  1097-0142     ISO Abbreviation:  Cancer     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-17     Completed Date:  2012-10-22     Revised Date:  2014-08-29    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3531-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 American Cancer Society.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Alleles*
Chromosome Deletion
Chromosome Disorders / genetics*
Chromosomes, Human, Pair 13 / genetics
Female
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*,  therapy
Male
Middle Aged
Prognosis
Treatment Outcome
Grant Support
ID/Acronym/Agency:
P30 CA016672/CA/NCI NIH HHS
Comments/Corrections
Comment In:
Cancer. 2012 Oct 15;118(20):5179; author reply 5179-80   [PMID:  22511321 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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