Document Detail

The progesterone receptor regulates implantation, decidualization, and glandular development via a complex paracrine signaling network.
MedLine Citation:
PMID:  22115959     Owner:  NLM     Status:  MEDLINE    
Many women are affected by infertility and reproductive-associated disease such as endometriosis or endometrial cancer. Successful pregnancy is dependent on a healthy uterus that is fit to receive and support a fertilized embryo. The uterus is an endocrine organ, responsive to the presence of the ovarian steroid hormones, estrogen and progesterone, which activate transcription of target genes through the binding of their cognate receptors, the estrogen receptor and the progesterone receptor. Progesterone signaling has been demonstrated to be critical for the initiation and continuance of pregnancy. Through the induction of Ihh, Wnt, and Bmp pathways within the epithelial and stromal compartments of the uterus, embryo attachment and implantation occur followed by decidualization of the surrounding stroma. Furthermore, these pathways have been shown to be involved in uterine glandular development. This review highlights the integral role of uterine progesterone-mediated paracrine signaling in gland development and pregnancy.
Margeaux Wetendorf; Francesco J DeMayo
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-11-17
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  357     ISSN:  1872-8057     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-30     Completed Date:  2012-10-23     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  108-18     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Decidua / physiology*
Embryo Implantation*
Paracrine Communication*
Receptors, Progesterone / metabolism*
Signal Transduction*
Uterus / cytology*,  metabolism
Grant Support
Reg. No./Substance:
0/Receptors, Progesterone

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