Document Detail


The progesterone positive feedback effect in women after ovariectomy.
MedLine Citation:
PMID:  23153029     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Various ovarian substances regulate the secretion of gonadotrophins during the menstrual cycle, but there are still several unclarified issues. The aim of this study was to investigate the positive feedback effect of progesterone during the immediate period following ovariectomy. Experiments were performed in 12 normally cycling women (aged 39-49 years). Following abdominal hysterectomy plus bilateral ovariectomy performed on cycle day 3 (day 0), the women received either estradiol via skin patches (days 0-7, n = 6, group 1) or estradiol as above plus vaginal progesterone (days 1-7, n = 6, group 2). Serum estradiol values increased similarly in the two groups. After the operation, serum progesterone levels decreased significantly in group 1, while in group 2 they remained stable becoming higher than in group 1 (p < 0.05). An LH and an FSH surge occurred in group 2 with the values after the peak returning to the pre-surge baseline. In contrast, in group 1 LH and FSH levels following an initial decrease, increased gradually until the end of the experiment. These results demonstrate that, despite a variable response to estrogens, the positive feedback effect of progesterone remained intact immediately after ovariectomy in women. It is suggested that it is the combining action of estradiol and progesterone that can ensure the expression of a positive feedback mechanism in women.
Authors:
Apostolos Zavos; Konstantinos Dafopoulos; Christina I Messini; Panagiotis Georgoulias; Christina Verikouki; George Anifandis; Antonios Garas; Ioannis E Messinis
Related Documents :
23517519 - Neural steroid sensitivity and aggression: comparing individuals of two songbird subspe...
23433789 - Free il-18 and il-33 cytokines in chronic spontaneous urticaria.
23964789 - Coenzyme q10 supplementation in infertile men with low-grade varicocele: an open, uncon...
24522699 - Effects of serum and plasma matrices on multiplex immunoassays.
24455599 - Alteration in plasma lipid profile in oral submucous fibrosis patients: a case control ...
24718309 - The pretreatment albumin to globulin ratio has predictive value for long-term mortality...
12094009 - Age-related changes in the regulation of luteinizing hormone secretion by estrogen in w...
16828859 - A review of sample handling considerations for reproductive and thyroid hormone measure...
2043989 - Allergen, bradykinin, and capsaicin increase outward but not inward macromolecular perm...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-16
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  -     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Portuguese adolescents' attitudes toward sexual minorities: transphobia, homophobia, and gender role...
Next Document:  Microfabricated Arrays for Splitting and Assay of Clonal Colonies.