Document Detail


A progesterone-induced blocking factor corrects high resorption rates in mice treated with antiprogesterone.
MedLine Citation:
PMID:  2220944     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Earlier we showed that because of the presence of functional progesterone receptors, lymphocytes of healthy pregnant women produced an immunomodulatory protein in the presence of progesterone, whereas those of nonpregnant persons did not. Progesterone-treated murine pregnancy lymphocytes release a similar factor. The present study reveals the biologic significance of this finding. Treatment of BALB/c mice that were 8 days pregnant with a progesterone receptor blocker (RU 486) resulted in 100% resorption of the fetuses. Simultaneous administration of the supernatant from progesterone-treated murine pregnancy spleen cells restored the resorption rate to the original 6% observed in untreated control animals. These data suggest that functional lymphocytic progesterone binding sites are needed for the maintenance of normal pregnancy. Because of the blockage of progesterone receptors and the consequent inability of the lymphocytes to produce the progesterone-induced blocking factor, abortion is initiated by immune factors. The fact that administration of the preformed blocking factor counteracted the effect of antiprogesterone treatment suggests that progesterone-mediated immunosuppression is needed for the maintenance of normal gestation.
Authors:
J Szekeres-Bartho; G Chaouat; R Kinsky
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  163     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1990-11-16     Completed Date:  1990-11-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1320-2     Citation Subset:  AIM; IM    
Affiliation:
Institute of Microbiology, University Medical School, Pecs, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Induced
Animals
Female
Fetal Resorption / physiopathology*
Immune Tolerance*
Litter Size
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mifepristone / pharmacology*
Pregnancy / physiology*
Progesterone / antagonists & inhibitors*
Chemical
Reg. No./Substance:
57-83-0/Progesterone; 84371-65-3/Mifepristone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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