| The proform of eosinophil major basic protein: a new maternal serum marker for adverse pregnancy outcome. | |
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MedLine Citation:
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PMID: 19626619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To establish the first trimester serum levels of the proform of eosinophil major basic protein (proMBP) in pregnancies with adverse outcome. Furthermore, to determine the screening performance using proMBP alone and in combination with other first trimester markers. METHODS: A case-control study was conducted in a primary hospital setting. The proMBP concentration was measured in cases with small-for-gestational age (SGA) (n = 150), spontaneous preterm delivery (n = 88), preeclampsia (n = 40), gestational hypertension (n = 10) and in controls (n = 500). Concentrations were converted to multiples of the median (MoM) in controls and groups were compared using Mann-Whitney U-test. Logistic regression analysis was used to determine significant factors for predicting adverse pregnancy outcome. Screening performance was assessed using receiver operating characteristic curves. RESULTS: The proMBP median was significantly reduced in pregnancies with SGA (0.81 MoM), spontaneous preterm delivery (0.83 MoM), preeclampsia (0.88 MoM) and gestational hypertension (0.60 MoM). The best screening performance was found for preeclampsia including the covariates proMBP and nulliparity yielding an area under the curve equal to 0.737 (p < 0.0005) and a 75% detection rate for a 30% false positive rate. CONCLUSION: The proMBP is a novel first trimester serum marker for adverse pregnancy outcome. |
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Authors:
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Kasper Pihl; Torben Larsen; Steen Rasmussen; Lone Krebs; Michael Christiansen |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 29 ISSN: 1097-0223 ISO Abbreviation: Prenat. Diagn. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-02 Completed Date: 2010-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 1013-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Artillerivej5, DK-2300 Copenhagen, Denmark. Kasper_Pihl@dadlnet.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biological Markers / blood Blood Proteins Case-Control Studies False Positive Reactions Female Humans Hypertension, Pregnancy-Induced / blood, epidemiology Infant, Newborn Infant, Small for Gestational Age Obstetric Labor, Premature / blood, epidemiology Pre-Eclampsia / blood, epidemiology Pregnancy Pregnancy Complications / blood, diagnosis*, epidemiology Pregnancy Outcome Pregnancy Trimester, First / blood Prognosis Protein Precursors / blood* Proteoglycans / blood* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Proteins; 0/Protein Precursors; 0/Proteoglycans; 147016-17-9/PRG2 protein, human |
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