| The profile of long-chain fatty acids in serum phospholipids: a possible indicator of copper status in humans. | |
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MedLine Citation:
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PMID: 3202098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In previous reports of experimental copper depletion in humans, it was difficult to reliably demonstrate biochemically that there was Cu depletion. In view of the changes in serum phospholipid fatty acid profiles in Cu-deficient rats, it was considered worthwhile to determine the effect of Cu depletion in humans on serum fatty acid profiles. Serum samples from the Cu-depletion study of Reiser et al were analyzed for phospholipid fatty acid composition. After the participants had been on the low copper diet for 11 wk, serum phospholipids contained 27% less oleic acid, 38% more arachidonic acid, and 94% more docosahexaenoic acid (all p less than 0.01) than samples taken from the same subjects before Cu depletion. These fatty acid changes were of a similar direction and magnitude to those in moderately Cu-depleted rats and may be useful as an index of moderate Cu depletion in humans. |
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Authors:
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S C Cunnane |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 48 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-01-17 Completed Date: 1989-01-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1475-8 Citation Subset: AIM; IM |
Affiliation:
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Efamol Research Institute, Kentville, Nova Scotia, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Copper / blood* Fatty Acids, Unsaturated / blood* Humans Male Middle Aged Nutritional Status Phospholipids / blood* Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated; 0/Phospholipids; 7440-50-8/Copper |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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