Document Detail


The profile of cardiac cytochrome c oxidase (COX) expression in an accelerated cardiac-hypertrophy model.
MedLine Citation:
PMID:  16132109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The contribution of the mitochondrial components, the main source of energy for the cardiac hypertrophic growth induced by pressure overload, is not well understood. In the present study, complete coarctation of abdominal aorta was used to induce the rapid development of cardiac hypertrophy in rats. One to two days after surgery, we observed significantly higher blood pressure and cardiac hypertrophy, which remained constantly high afterwards. We found an early increased level of cytochrome c oxidase (COX) mRNA determined by in-situ hybridization and dot blotting assays in the hypertrophied hearts, and a drop to the baseline 20 days after surgery. Similarly, mitochondrial COX protein level and enzyme activity increased and, however, dropped even lower than baseline 20 days following surgery. In addition, in natural hypertension-induced hypertrophic hearts in genetically hypertensive rats, the COX protein was significantly lower than in normotensive rats. Taken together, the lower efficiency of mitochondrial activity in the enlarged hearts of long-term complete coarcted rats or genetically hypertensive rats could be, at least partially, the cause of hypertensive cardiac disease. Additionally, the rapid complete coarctation-induced cardiac hypertrophy was accompanied by a disproportionate COX activity increase, which was suggested to maintain the cardiac energy-producing capacity in overloaded hearts.
Authors:
Wei-Wen Kuo; Chia-Yih Chu; Chieh-Hsi Wu; James A Lin; Jer-Yuh Liu; Tsung-Ho Ying; Shin-Da Lee; Yi-Hsien Hsieh; Chu-Hsien Chu; Ding-Yu Lin; Hsi-Hsien Hsu; Chih-Yang Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-10
Journal Detail:
Title:  Journal of biomedical science     Volume:  12     ISSN:  1021-7770     ISO Abbreviation:  J. Biomed. Sci.     Publication Date:  2005  
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421567     Medline TA:  J Biomed Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  601-10     Citation Subset:  IM    
Affiliation:
Institute of Biochemistry, Chung-Shan Medical University, Taichung, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Western
Body Weight
Electron Transport Complex IV / biosynthesis*,  chemistry,  metabolism,  physiology*
Femoral Artery / pathology
Gene Expression
Hypertension / pathology*
Hypertrophy / pathology*
Hypertrophy, Left Ventricular / pathology
In Situ Hybridization
Male
Mitochondria / pathology
Models, Biological
Myocardium / pathology
Organ Size
Oxygen / chemistry
RNA / chemistry
RNA, Messenger / metabolism
Rats
Rats, Sprague-Dawley
Time Factors
Chemical
Reg. No./Substance:
0/RNA, Messenger; 63231-63-0/RNA; 7782-44-7/Oxygen; EC 1.9.3.1/COX5B protein, human; EC 1.9.3.1/Electron Transport Complex IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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