Document Detail

The profile of cardiac cytochrome c oxidase (COX) expression in an accelerated cardiac-hypertrophy model.
MedLine Citation:
PMID:  16132109     Owner:  NLM     Status:  MEDLINE    
The contribution of the mitochondrial components, the main source of energy for the cardiac hypertrophic growth induced by pressure overload, is not well understood. In the present study, complete coarctation of abdominal aorta was used to induce the rapid development of cardiac hypertrophy in rats. One to two days after surgery, we observed significantly higher blood pressure and cardiac hypertrophy, which remained constantly high afterwards. We found an early increased level of cytochrome c oxidase (COX) mRNA determined by in-situ hybridization and dot blotting assays in the hypertrophied hearts, and a drop to the baseline 20 days after surgery. Similarly, mitochondrial COX protein level and enzyme activity increased and, however, dropped even lower than baseline 20 days following surgery. In addition, in natural hypertension-induced hypertrophic hearts in genetically hypertensive rats, the COX protein was significantly lower than in normotensive rats. Taken together, the lower efficiency of mitochondrial activity in the enlarged hearts of long-term complete coarcted rats or genetically hypertensive rats could be, at least partially, the cause of hypertensive cardiac disease. Additionally, the rapid complete coarctation-induced cardiac hypertrophy was accompanied by a disproportionate COX activity increase, which was suggested to maintain the cardiac energy-producing capacity in overloaded hearts.
Wei-Wen Kuo; Chia-Yih Chu; Chieh-Hsi Wu; James A Lin; Jer-Yuh Liu; Tsung-Ho Ying; Shin-Da Lee; Yi-Hsien Hsieh; Chu-Hsien Chu; Ding-Yu Lin; Hsi-Hsien Hsu; Chih-Yang Huang
Related Documents :
21404079 - Non-invasive monitoring of central blood pressure by electrical impedance tomography: f...
8829819 - Hypertension from carotid occlusion decreases renal papillary plasma flow, hypotension ...
3772099 - Calcium stimulates vasopressin release.
7771559 - Endothelin-1 and its binding sites are upregulated in pressure overload cardiac hypertr...
25239299 - Effects of a constant rate infusion of medetomidine-propofol on isoflurane minimum alve...
12147319 - Prenatal malnutrition-induced hypertension in young rats is prevented by neonatal capsa...
635749 - The effect of a mechanical venous pump on the circulation of the feet in the presence o...
19130799 - Angiotensin converting enzyme gene polymorphism (insertion/deletion) and hypertension i...
2994989 - Enalapril maleate versus captopril. a comparison of the hormonal and antihypertensive e...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-10
Journal Detail:
Title:  Journal of biomedical science     Volume:  12     ISSN:  1021-7770     ISO Abbreviation:  J. Biomed. Sci.     Publication Date:  2005  
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421567     Medline TA:  J Biomed Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  601-10     Citation Subset:  IM    
Institute of Biochemistry, Chung-Shan Medical University, Taichung, Taiwan, ROC.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blotting, Western
Body Weight
Electron Transport Complex IV / biosynthesis*,  chemistry,  metabolism,  physiology*
Femoral Artery / pathology
Gene Expression
Hypertension / pathology*
Hypertrophy / pathology*
Hypertrophy, Left Ventricular / pathology
In Situ Hybridization
Mitochondria / pathology
Models, Biological
Myocardium / pathology
Organ Size
Oxygen / chemistry
RNA / chemistry
RNA, Messenger / metabolism
Rats, Sprague-Dawley
Time Factors
Reg. No./Substance:
0/RNA, Messenger; 63231-63-0/RNA; 7782-44-7/Oxygen; EC protein, human; EC Transport Complex IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Attenuation of post-ischemia reperfusion injury by thaliporphine and morphine in rat hearts.
Next Document:  Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and ...