Document Detail

The production of platelet-activating factor during hemodialysis.
MedLine Citation:
PMID:  2613357     Owner:  NLM     Status:  MEDLINE    
Regenerated cellulosic membranes (CU) induced the aggregation of plasma-free human neutrophils when recirculated in a dynamic model of dialysis without the patient on the circuit. Neutrophil aggregation was linked to the production of PAF by these cells. In the absence of detectable PAF production, no neutrophil aggregation occurred, as observed during recirculation with polymethylmethacrylate (PMMA) membranes. With polycarbonate (PC), PAF production and aggregation of neutrophils were both almost half the values with CU. PAF production was studied in ten hemodialysis (HD) patients tested twice with CU and once with PC and PMMA membranes. PAF was extracted in the venous blood during filling of the dialyser for 9/20 of patients with CU (3.1 +/- 2.9 ng/ml, mean +/- 1 S.D.) a membrane that induced marked leukopenia (greater than 50% of basal values at 15 min), C3a des Arg generation (greater than 500% at 5 min), and plasma levels of the elastase-alpha 1-proteinase inhibitor complex (greater than 500% at the end of HD). Membranes such as PC and PMMA showing intermediate or low potential to induce leukopenia and C3a des Arg generation, respectively, did not trigger the production and release of PAF in detectable amounts at any interval. However, with PMMA, plasma neutrophil elastase was significantly higher than baseline at the end of dialysis. These levels were not significantly different (p less than 0.05) from those observed with CU and PC membranes.
C Tetta; G Segoloni; A Pacitti; G Regis; M Salomone; E Turello; G Camussi; A Vercellone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  12     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-03-12     Completed Date:  1990-03-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  766-72     Citation Subset:  IM    
Chair of Medical Nephrology, Università degli Studi of Torino, Italy.
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MeSH Terms
Cell Aggregation
Membranes, Artificial*
Middle Aged
Neutrophils / metabolism*
Platelet Activating Factor / metabolism*
Polycarboxylate Cement
Renal Dialysis*
Reg. No./Substance:
0/Membranes, Artificial; 0/Methylmethacrylates; 0/Platelet Activating Factor; 0/Polycarboxylate Cement; 25766-59-0/polycarbonate; 9004-34-6/Cellulose

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